Figure 4.

Trial-to-trial mean (TTM) and trial-to-trial variability (TTV) in various functional networks. A. network template includes auditory cortex (Audi), default mode network (DMN), frontoparietal (FP), salience/cingulo-opercular (Sal), language (Lan), dorsal attention (DA), sensorimotor (SM), visual (Vis), and thalamus (Tha). B. TTM values and statistical significances of different networks. C. TTV values and statistical significances of different networks. Results without and with global signal regression (No-GSR and GSR) are shown. *Significant differences against zero by one-sample t-tests. ^#Significant differences against wakefulness by paired sample t-tests (i.e. sedation vs. wakefulness, and anesthesia vs. wakefulness). ^$Significant differences against sedation by paired sample t-tests (i.e. anesthesia vs. sedation). Error bars indicate ±SEM. All results were FDR corrected. The insets in B and C show the effect size (Cohen’s d) for the mean differences against zero, where d=0.2 is considered a ‘small’ effect size, 0.5 represents a ‘medium’ effect size and 0.8 a ‘large’ effect size. The range limit of y-axis is from 0–0.8 for illustrative purpose. Overall, all reported significant results are close to or above d=0.8.