Table 3.

Total mortality following the Trials of Hypertension Prevention through 2013 by categories of weight change, among 3828 participants fulfilling eligibility criteria for TOHP weight loss intervention (high-weight stratum).^*

	% Weight Change				P for Trend	HR per 5% change†	P Value
	Loss > 5%	Loss 0-<= 5%	Gain 0-< 5%	Gain 5%+
Deaths/ Total (%)
TOHP I	22/249 (8.8)	44/458 (9.6)	73/632 (11.6)	16/138 (11.6)	0.18
TOHP II	19/307 (6.2)	49/643 (7.6)	55/935 (5.9)	35/466 (7.5)	0.92
Model 1
HR	0.86	0.95	1.00	1.34	0.052	1.14	0.018
95%CI	0.60-1.23	0.72-1.24	(Reference)	0.96-1.86		1.02-1.27
Model 2
HR	0.82	0.94	1.00	1.29	0.046	1.14	0.019
95%CI	0.57-1.18	0.72-1.23	(Reference)	0.92-1.80		1.02-1.28

^*From Cox proportional hazards regression models stratified by trial phase and adjusted as follows: Model 1 (age, sex, race/ethnicity, clinic, baseline weight, and treatment assignments), Model 2 (Model 1 variables plus education status, alcohol use, smoking, exercise, sodium and potassium excretion, family history of cardiovascular disease, and interactions of sodium intervention with sodium and potassium). HR, hazard ratio; CI, confidence interval.

^†Weight change is winsorized at 3 standard deviation.