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. Author manuscript; available in PMC: 2019 Aug 9.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2018 Dec 12;11(3):e1443. doi: 10.1002/wsbm.1443

Figure 5. Modeling the edgetic effects of genetic variants supports exploration of disease mechanisms.

Figure 5.

A) Pleiotropy can result when different variants in the same gene affect different interactions in which a protein participates. B) Variants at reciprocal interfaces of interacting proteins can contribute to locus heterogeneity.