Table 2.

Effect of ML302F on Meropenem Minimal Inhibitory Concentrations for VIM-1-Expressing Enterobacteriaceae

Strain	Meropenem MIC (μg ml−1)	Meropenem Resistant/Intermediate/Susceptible (clinical strains; EUCAST*)	Meropenem MIC (μg ml−1) + 10 μg ml−1 ML302F	Meropenem Resistant/Intermediate/Susceptible (clinical strains; EUCAST*)	Fold difference in MIC
E. coli TOP1O (control)	≤ 0.25		≤ 0.25		0
K. pneumoniae NCTC 5055 (control)	≤ 0.25		≤ 0.25		0
K. pneumoniae Kpn20	32	R	8	R	4
K. pneumoniae 08Y70	32	R	2	S	16
K. pneumoniae 08Z37	16	R	4	I	4
K. pneumoniae 09A69	32	R	4	I	8
K. pneumoniae 09B51	8	R	1	S	8
K. pneumoniae 09B53	8	R	1	S	8
K. pneumoniae 09B61	32	R	4	I	8
K. pneumoniae 09B76	64	R	32	R	2
K. pneumoniae 09C12	64	R	16	R	4
K. pneumoniae 09C74	256	R	128	R	2
K. pneumoniae 09C77	32	R	4	I	8
K. pneumoniae 09D21	16	R	1	S	16
K. pneumoniae 10D60	16	R	2	S	8
K. pneumoniae 10F53	16	R	2	S	8
K. pneumoniae 10F74	32	R	8	R	4
K. pneumoniae 1–57	16	R	2	S	8
K. pneumoniae 1–60	16	R	4	I	4
K. pneumoniae 1–61	128	R	128	R	0
K. pneumoniae 1–70	32	R	4	I	8
K. pneumoniae 10I28	16	R	0.5	S	32
E. coli08Y79	8	R	2	S	4
E. coli 09B20	2	S	0.5	S	4
E. coli 09D25	2	S	≤ 0.25	S	≥ 8
E. coli 1–37	1	S	≤ 0.25	S	≥ 4
E. coli 1–47	16	R	4	I	4
E. coli 10F75	2	S	2	S	0
E. coli 2–4	2	S	0.5	S	4

^*EUCAST breakpoints [61]: resistant MIC ≥ 8 mg l⁻¹; susceptible MIC ≤ 2 mg l⁻¹. (CLSI breakpoints are resistant MIC ≥ 4 mg l⁻¹; susceptible MIC ≤ 1 mg l⁻¹ [58])