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. Author manuscript; available in PMC: 2019 Jul 12.

Published in final edited form as: Bipolar Disord. 2018 Dec 28;21(2):108–116. doi: 10.1111/bdi.12735

Table 1.

Neuroepigenetic effects of histone deacetylases in PPN gamma oscillations⁸⁹.

Agent	Conc’n Role		Effect
Trichostatin A (TSA)	1 uM	Inhibits HDAC class I	No effect on oscillations
		Inhibits HDAC class II	Blocks oscillations
MC1568	1 uM	Inhibits HDAC class IIa	Blocks oscillations
MS275	500 nM	Inhibits HDAC class I	No effect on oscillations
Tubastatin A	150 nM	Inhibits HDAC class IIb	No effect on oscillations
KN-93	1 uM	Inhibits CaMKII	Reduced effects of TSA

Note: HDAC class Is remains in the nucleus while HDAC class IIs can move to cytoplasm.