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. Author manuscript; available in PMC: 2008 Aug 6.
Published in final edited form as: Nat Prod Rep. 2008 Apr 14;25(4):719–737. doi: 10.1039/b706296f

Scheme 16.

Scheme 16

Summary of Schreiber’s pairwise use of Ferrier and Pauson–Khand reactions for the synthesis of polycyclic skeletons. Reagents and conditions: (1) cat. BF3·OEt2, CH2Cl2, −78 to −20 °C, 92%; (2) TBAF, AcOH, THF; purification, 72%; (3) Co2(CO)8, CH2Cl2; NMO, CH2Cl2-CH3CN.