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. Author manuscript; available in PMC: 2010 Apr 14.
Published in final edited form as: J Neurosci. 2009 Oct 14;29(41):12855–12864. doi: 10.1523/JNEUROSCI.1699-09.2009

Figure 5. AVV-PRS-hKir2.1 does not increase allodynia in spared nerve injury model.

Figure 5

A) To assess the effect of transduction with AVV-PRS-hKir2.1 on the development of the signs of neuropathic pain, animals received lumbo-spinal injection of either AVV-PRS-hKir2.1 or AVV-PRS-EGFP one week prior to SNI. Each group was then followed for two weeks and assessed for the development of mechanical and cold allodynia. Following spinal AVV administration both groups of SNI animals developed significant (B) mechanical allodynia (von Frey hair threshold) and (C) cold allodynia (acetone drop induced paw withdrawal). Transduction of the pontospinal NAergic neurons with AVV-PRS-hKir2.1 did not significantly alter the expression of mechanical or cold allodynia compared to AVV-PRS-EGFP (two-way rmANOVA).