Table 2.
| Parameter | AVV-PRS-EGFP (n=18) |
AVV-PRS-hKir2.1 (n=19) |
|---|---|---|
| Membrane potential (mV) | −58.5 [−57.2 to −64.0] |
−56.6 [−46.5 to −58.6] |
| Input resistance (MΩ) | 327±14 | 256±23 * |
| Spontaneous firing rate ( Hz) | 1.0 [0.35 to 2.1] |
0.2 * [0.0 to 0.9] |
| Spike threshold (mV) | −37±1.4 | −35±2.4 |
| Spike amplitude (mV) | 60±3 | 56±4 |
| Spike duration (⅓ max, ms) | 5.3 [3.5 to 7.2] |
5.2 [3.7 to 7.6] |
| AHP amplitude (mV) | 23 [18 to 24] |
23 [21 to 26] |
| AHP duration (ms) | 124 [81 to 181] |
182 [98 to 250] |
Comparison of membrane properties and action potential parameters of LC neurons in slice culture transduced with AVV-PRS-EGFP or AVV-PRS-hKir2.1. Data quoted as mean±SEM or median [interquartile range] and significance assessed using unpaired t-test or Mann Whitney test as appropriate.
*
P<0.05.