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. Author manuscript; available in PMC: 2008 Dec 5.
Published in final edited form as: FEBS Lett. 2008 Oct 16;582(27):3711–3718. doi: 10.1016/j.febslet.2008.10.006

Fig. 2.

Fig. 2

A schematic model for the regulation of Lck activity in T-cells. The activity of Lck in lipid rafts is low owing to the recruitment of Csk by PAG/Cbp, LIME and possibly an additional, as yet unknown, adaptor to these domains. Movement of Lck out of lipid rafts or transient association of lipid rafts with CD45 could result in Y-505 dephosphorylation and increase in Lck activity.