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. Author manuscript; available in PMC: 2008 Dec 5.
Published in final edited form as: FEBS Lett. 2008 Oct 16;582(27):3711–3718. doi: 10.1016/j.febslet.2008.10.006

Fig. 3.

Fig. 3

Changes in the membrane of lupus T-cells may associate with their autoimmune phenotype. The higher cholesterol and GM1 content of lupus T-cell membrane may result in larger and/or less mobile lipid rafts. This in combination with the increased association of CD45 with lipid rafts, higher Lck activity, and changes in the actin cytoskeleton seen in these cells could reduce the threshold for activation.