Table 2.
Pharmacokinetic parameters of resveratrol and its three major metabolites in plasma of healthy volunteers who received daily oral resveratrol for between 21 and 28 days (n=10 per dose level).
| Parameter |
|||||
|---|---|---|---|---|---|
| Cmax*† (ng/mL) |
Cav*† (ng/mL) |
Tmax† (h) |
T½† (h) |
AUClast† (ngxh/mL) |
|
| Resveratrol Dose (g) |
|||||
| 0.5 | 43.8 (89.4) [0.19] | 9.93 (69.7) [0.04] | 1.00 (0.25-5.0) | 4.77(62.1) | 175 (83.7) |
| 1.0 | 141 (68.9) [0.62] | 22.8 (68.4) [0.10] | 1.00 (0.25-1.82) | 9.70 (37.5) | 503 (79.3) |
| 2.5 | 331 (59.2) [1.45] | 48.1(46.5) [0.21] | 1.00 (0.23-4.97) | 9.17 (42.0) | 1250 (40.0) |
| 5.0 | 967 (53.5) [4.24] | 126 (55.8) [0.55] | 1.08 (0.5-1.5) | 7.85 (25.1) | 4097 (107 |
| Resveratrol-4′-O- glucuronide Dose (g) |
|||||
| 0.5 | 186 (56.7) [0.82] | 50.2 (51.1) [0.22] | 1.27 (1.0-5.0) | 3.78 (42.2) | 1331 (56.4) |
| 1.0 | 710 (57.9) [3.12] | 178 (64.8) [0.78] | 1.50 (0.83-5.0) | 5.77 (44.6) | 3774 (53.2) |
| 2.5 | 1137 (88.0) [4.99] | 323 (66.9) [1.42] | 1.50 (0.25-5.0) | 8.14 (38.6) | 7245 (54.4) |
| 5.0 | 2323 (45.5) [10.2] | 667 (61.3) [2.93] | 1.50 (1.0-5.0) | 7.55 (21.2) | 19984 (59.0) |
| Resveratrol-3-O- glucuronide Dose (g) |
|||||
| 0.5 | 184 (86.3) [0.81] | 37.7 (56.2) [0.17] | 1.27 (1.0-5.0) | 4.98 (41.6) | 875 (51.4) |
| 1.0 | 588 (48.4) [2.45] | 94.4 (28.9) [0.42] | 1.50 (0.83-5.0) | 5.50 (24.5) | 2087 (37.7) |
| 2.5 | 1546 (107) [6.78] | 204 (64.0) [0.89] | 1.42 (1.0-1.5) | 6.43 (40.8) | 5300 (47.1) |
| 5.0 | 3886 (48.6) [17.1] | 649 (34.8) [2.85] | 1.50 (0.5-1.6) | 5.19 (52.7) | 22084 (93.9) |
| Resveratrol-3-O- sulfate Dose (g) |
|||||
| 0.5 | 563 (35.1) [2.47] | 118 (26.9) [0.52] | 1.04 (1.0-5.0) | 3.09 (15.3) | 3558 (51.6) |
| 1.0 | 1694 (35.2) [7.43] | 377 (48.7) [1.65] | 1.50 (0.83-5.0) | 7.37 (51.4) | 9464 (42.3) |
| 2.5 | 2292 (50.7) [10.1] | 604 (43.8) [2.65] | 1.33 (1.0-1.5) | 6.84 (40.6) | 15638 (39.0) |
| 5.0 | 4172 (40.3) [18.3] | 1384 (42.3) [6.07] | 1.25 (0.25-5.0) | 7.98 (29.6) | 38900 (49.5) |
Cmax=maximal plasma concentration. Cav=average plasma concentration. Tmax=time of maximal plasma concentration (Cmax). T½=apparent first-order elimination half- live. AUClast=area under the plasma concentration versus time curve from time 0 to the last sampling blood draw collected.
*
Mean value in ng/mL,
†
CV% (round brackets), mean value in nmol/mL [square brackets],
†
Median (range).