Skip to main content
. Author manuscript; available in PMC: 2011 May 27.
Published in final edited form as: Mol Ther. 2011 Jan 11;19(4):642–649. doi: 10.1038/mt.2010.293

Figure 3.

Figure 3

Rod-derived ERG following combined suppression and replacement therapy.

The right eyes of P5 P347S mice were subretinally injected with a mixture of 6.0×108 vp AAV-S and 1.8×1010 vp AAV-R while the left eyes were injected with 6.0×108 vp AAV-C. Six (n=17) or twenty weeks (n=12) post-injection, mice were dark-adapted overnight and rod-isolated ERG responses recorded from both eyes. a and b: overlays of the ERG recordings; green and blue lines represent recordings from combined suppression and replacement therapy (S+R) and control (C)-injected eyes, respectively. c: mean ERG b-wave amplitudes (μV). Green and blue columns represent values corresponding to S+R and control injected eyes, respectively. Error bars represent SD values and *** represent p<0.001.