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. Author manuscript; available in PMC: 2012 Sep 6.
Published in final edited form as: Eur J Immunol. 2011 Jan 11;41(2):276–281. doi: 10.1002/eji.201041252

Figure 1.

Figure 1

Signal transduction pathways and outcomes of Syk/CARD9-coupled receptor signalling in antifungal immunity. Dectin-1/2 and Mincle all signal via Syk kinase, which associates to either the ITAM-like motif of Dectin-1 (shown by red Y in white boxes) or the ITAM on FcRγ (denoted by dark blue Y in white boxes) that associates with Dectin-2 and Mincle. Syk signalling results in a complex of CARD9, BCL10 and MALT1 that ultimately leads to the activation of transcription factors, including NF-κB. These transcription factors mediate the translation of key cytokines that help to promote Th1/Th17 differentiation, which in turn stimulates antifungal mechanisms from innate cells such as neutrophils and macrophages.