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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: J Neurosci. 2011 Apr 20;31(16):6174–6187. doi: 10.1523/JNEUROSCI.5464-10.2011

Figure 1.

Figure 1

Deletion of Robo1 receptor increases the number of GABAergic neurons in the cerebral cortex and striatum. (A,B) Coronal sections through the brains of a Robo1+/−;GAD67GFP mouse (A) and a Robo1−/−;GAD67-GFP littermate (B) at E15.5. Areas bracketed in A and B are shown at higher magnifications in C and D, respectively, whereas boxes in A and B are shown at higher magnifications in E and F, respectively. (E’,F’) The boxed areas in E and F are shown at an even higher magnification. (G) Counts of GAD67-GFP+ cells show increased number throughout the rostral-caudal extent of the striatum of Robo1−/− mice at E15.5. Scale bars: 500 μm (A,B); 150 μm (C-F’). **p<0.01. Abbreviations: CP, cortical plate; Cx, cerebral cortex; hem, cortical hem; IZ, intermediate zone; LV, lateral ventricle; MZ, marginal zone; Sp, septum; Str, striatum; SVZ, subventricular zone; VZ, ventricular zone.