Figure 7.
GN11 cells express Robo receptors and respond to class 3 semaphorins and Slit1. (A) RT-PCR analysis showed expression of Robo1-3 in GN11 cells. (B) Immunohistochemistry confirmed the expression of Robo receptors in GN11 cells. (C,D) Quantification of GN11 cell migration in a Boyden’s chamber, containing Sema3A, Sema3F, Slit1 or control (CM-myc) conditioned media (C). (D) Robo1-DN transfected GN11 cells are less responsive to Sema3A than control (GFP) transfected cells. Scale bar: 100 μm. **p<0.01; ***p<0.001.
