Table 4. Functional characterization of β₂157 mutant GABA_A receptors.

Mutant	LogEC50 ± SEM	EC50 (μm)	EC50mut/EC50wt	n H	n
α 1 β 2	−5.457 ± 0.04	3.5		1.2	4
α 1 β 2 157-Phe	−2.846 ± 0.10a	1400	400	0.9	6
α 1 β 2 157-4-F-Phe	−5.514 ± 0.15	3.0	0.86	1.2	6
α 1 β 2 157-3,5-F2-Phe	−3.371 ± 0.04a	420	120	2.0	4
α 1 β 2 157-3,4,5-F3-Phe	−3.950 ± 0.08a	110	32	1.7	4
α 1 β 2 157-4-MeO-Phe	−5.294 ± 0.10	5	1.4	1.2	3
α 1 β 2 157-4-Me-Phe	−3.817 ± 0.15a	150	43	0.8	3

^aDenotes logEC₅₀ values statistically significantly different from wild type by one-way ANOVA; p < 0.01.