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. Author manuscript; available in PMC: 2009 Mar 2.
Published in final edited form as: J Neurosci. 2007 Jan 24;27(4):886–892. doi: 10.1523/JNEUROSCI.4791-06.2007

Table 5. Functional characterization of β2205 mutant GABAA receptors.

Mutant LogEC50 ± SEM EC50 (μm) EC50mut/EC50wt n H n
α 1 β 2 −5.457 ± 0.04 3.5 - 1.2 4
α 1 β 2 205-Phe −4.082 ± 0.04a 80 24 1.4 5
α 1 β 2 205-4-F-Phe −5.810 ± 0.08 1.5 0.43 1.9 3
α 1 β 2 205-3,5-F2-Phe −4.174 ± 0.06a 70 20 1.9 4
α 1 β 2 205-3,4,5-F3-Phe −4.039 ± 0.05a 90 26 2.5 4
a

Denotes logEC50 values statistically significantly different from wild type by one-way ANOVA; p < 0.01.