Table 3.
Association Between Neuropsychological Traits and Candidate Gene Variants Genotyped in the Combined Sample Using QTDT Analysis
|
DAOA
|
COMT
|
||||||
|---|---|---|---|---|---|---|---|
| Neuropsychological Trait | rs3916966 | rs2391191 | rs2153674 | rs701567 | rs954580 | rs4680 | rs165599 |
| General Intellectual Functioning (WAIS-R) | |||||||
| General ability (Vocabulary) | .0015 | .0002 | .0086 | .0083 | .0051 | .1381 | .1801 |
| Abstraction (Similarities) | .0010 | .0003 | .0063 | .0173 | .1428 | .1191 | .2103 |
| Psychomotor speed (Digit Symbol) | .0013 | .0034 | .0953 | .0125 | .2591 | .0986 | .0051 |
| Visuospatial ability (Block Design) | 4.00E-06a | 5.00E-06a | .0638 | .0108 | .0392 | .0191 | .0007 |
| Attention, Working Memory (WMS-R) | |||||||
| Auditory attention (Digit Span forward) | .0091 | .0088 | .0991 | .1948 | .0724 | .2769 | .5932 |
| Verbal working memory (Digit Span backward) | .0298 | .0213 | .1089 | .4111 | .6239 | .4017 | .8425 |
| Visual attention (Visual Span forward) | .1899 | .1374 | .6787 | .2073 | .2443 | .8875 | .9947 |
| Visual working memory (Visual Span backward) | .7120 | .5995 | .9652 | .7439 | .5356 | .7039 | .4952 |
| Verbal and Visual Memory (WMS-R) | |||||||
| Immediate verbal memory (Logical Memory I) | .1176 | .0602 | .4636 | .7139 | .7698 | .9536 | .8925 |
| Delayed verbal memory (Logical Memory II) | .1076 | .0638 | .8161 | .5091 | .4862 | .5853 | .4035 |
| Immediate visual memory (Visual Reproduction I) | .0047 | .0047 | .2174 | .2841 | .1352 | .0628 | .1468 |
| Delayed visual memory (Visual Reproduction II) | .0005 | .0010 | .2658 | .1316 | .2061 | .1200 | .2613 |
| Verbal Learning and Memory (CVLT) | |||||||
| Free short delay recall | .0032 | .0024 | .0537 | .1016 | .1397 | .0891 | .4644 |
| Free long delay recall | .0443 | .0206 | .2987 | .5264 | .7442 | .0054 | .0570 |
| Recognition memory | .0173 | .0079 | .1617 | .4569 | .5709 | .1076 | .4686 |
| Retention | .9571 | .4473 | .4304 | .8079 | .2869 | .0391 | .0016 |
| Executive Functions | |||||||
| Stroop Interference score | .0162 | .0060 | .3567 | .0047 | .3510 | .3090 | .7938 |
| Semantic fluency (COWAT) | .0195 | .0239 | .8410 | .0168 | .3594 | .5887 | .4003 |
| Phonemic fluency (COWAT) | .4183 | .4524 | .0369 | .4284 | .4841 | .6706 | .5438 |
COMT, catechol-O-methyl transferase; COWAT, Controlled Oral Word Association Test; CVLT, California Verbal Learning Test; DAOA, d-amino acid oxidase activator; WAIS-R, Wechsler Adult Intelligence Scale-Revised; WMS-R, Wechsler Memory Scale-Revised; QTDT, Quantitative Transmission Disequilibrium Test.
a
p values that remained significant (p < .05) after conservative Bonferroni correction.