TABLE IV.

Regions of significant activation from Model 2: Activation peaks related to task (combining selection and specified conditions) and action-selection (selection versus specified trials), in relation to age, disease severity, and medication status

	Region		X	Y	Z	t
Task vs. Rest
Controls Aging vs. PDOn Aging	Lateral Prefrontal Cortex	R	52	34	10	3.97
	SMA	L	−4	0	56	3.96
	Pre-motor Cortex	L	−34	−6	64	4.49
	Thalamus	R	16	−6	8	4.01
	Cerebellum	R	30	−52	−26	5.07
Controls Aging vs. PDOff Aging*	Cerebellum	R	30	−52	−26	3.45
PDOff Aging vs. PDOn Aging	Superior Orbital Gyrus	R	20	50	−6	4.84
	Anterior Cingulate	L	−4	26	24	4.63
	Insula	R	36	−22	8	3.92
	Middle Temporal Gyrus	L	−48	−20	−16	4.49
	Thalamus	R	10	−18	−4	4.16
PDOn vs. PDOff**	PreSMA	L	−12	24	54	3.06
Action-Selection vs. Specified
PDOn and PDOff: Disease   Severity (negative correlation)	Insula	L	−42	10	−8	5.1
	Superior Parietal	L	−30	−52	64	4.86
PDOff vs. PDOn	Ventral Premotor Cortex	R	54	−4	22	4.95
		R	30	−22	22	4.87
	Insula	L	−42	−24	14	4.27
	Hippocampus	R	12	−40	16	4.21

R, right; L, left; XYZ, coordinates of maximal activated voxel in standard anatomic space using the MNI template; t, Maximum t level at this voxel. P < 0.05 FDR, except.

^*P < 0.001 uncorrected.

^**P < 0.05 uncorrected.