Table 1. Clinical features of patient cohort.

All patients received bilateral STN DBS electrodes except for case 4. The dose of pramipexole is given as a salt. Psychiatric co-morbidity: mania and compulsivity (1 case), hypersexuality (2 cases), depression (1 case), past history of gambling on dopamine agonist (1 case).

Case	Age (yrs)/ Sex	Disease duration (yrs)	Predominant symptoms (in addition to akinesia)	Pre-op medication (total daily dose)	UPDRS ON/OFF medication	UPDRS OFF medication /ON DBS	Remarks
1	40/M	10	Gait impairment, tremor	Levodopa 1200mg Pramipexole 5mg	9/30	21	Additional tics from age 12
2	55/M	15	Tremor, freezing, motor fluctuations	Levodopa 1000mg Ropinirole16mg Selegiline10mg Amantadine100mg	5/19	18
3	59/F	13	Gait freezing, dyskinesias	Levodopa 500mg Cabergoline 1mg Amantadine 100mg Apomorphine 2mg	10/36	11	Recording done ON medication only. Cluster headache
4	45/F	8	Tremor	Ropinirole 27mg	−/50	42	DBS lead only in the right STN. The patient was intolerant of Levodopa so recording done OFF medication only
5	58/F	14	Gait freezing, pain, dyskinesias, motor fluctuations	Levodopa 250mg Pramipexole 4mg	18/71	15*
6	64/F	8	Tremor, dyskinesias	Levodopa 500mg Ropinirole 17mg Amantadine 300mg Rasagline 1mg	18/51	23#	Recording done ON medication only. Hypothyroidism
7	51/M	9	Gait impairment, tremor	Levodopa 800 mg Rasagiline 1mg	21/49	19$	REM sleep disorder Previous dopa dysregulation
8	60/M	15	Dyskinesias, gait freezing, tremor	Levodopa 1300mg Ropinirole 18mg Selegiline 10mg Amantadine 200mg	10/56	23
9	54/M	8	Gait impairment, dyskinesias	Levodopa 1200mg Cabergoline 4mg Entacapone 800mg Amantadine 300mg	9/38	15#
10	66/M	8	Freezing, motor fluctuations, dyskinesias, tremor	Levodopa 800mg Pramipexole 2000mg Rasagline 1mg Amantadine 200mg Apomorphine 4-8mg	18/72	21#	Recording done ON medication only
11	48/M	11	Gait freezing, tremor	Levodopa 1250mg Rasagiline 1mg Entacapone 500mg	16/72	25$
12	63/F	9	Tremor, pain	Rotigotine 4mg Rasagiline 1mg	−/51	12£	LRRK2 mutation. Patient was intolerant to levodopa, so recording was done OFF medication only.
13	61/M	9	Gait freezing, tremor	Levodopa 1800mg Pramipexole 500micrograms	5/28	19
14	58/F	10	Dystonia, dyskinesia, motor fluctuations	Levodopa 450mg Pramipexole 3mg Rasagiline 2mg	16/55	16$
15	52/M	12	Dystonia	Levodopa 950mg Rotigotine 4mg Rasagiline 1mg	10/35	26
16	58/M	13	Gait freezing	Levodopa 1200mg Amantadine 400mg Entacapone 600mg Rasagiline 1mg	25/43	17
17	57/M	17	Gait impairment, pain, dyskinesias	Levodopa 1550mg Entacapone 1600mg Selegiline 10mg Amantadine 200mg	14/54	32

All UPDRS scores OFF medication / ON DBS were assessed at either 6 months (#), 8 months (*), 10 months ($) or 1 year (unmarked). Subject 9 was assessed on Rasagiline 1mg ON DBS (£).