Table 1. Clinical features of patient cohort.
Case | Age (yrs)/ Sex |
Disease duration (yrs) |
Predominant symptoms (in addition to akinesia) |
Pre-op medication (total daily dose) |
UPDRS ON/OFF medication |
UPDRS OFF medication /ON DBS |
Remarks |
---|---|---|---|---|---|---|---|
1 | 40/M | 10 | Gait impairment, tremor |
Levodopa 1200mg Pramipexole 5mg |
9/30 | 21 | Additional tics from age 12 |
2 | 55/M | 15 | Tremor, freezing, motor fluctuations |
Levodopa 1000mg Ropinirole16mg Selegiline10mg Amantadine100mg |
5/19 | 18 | |
3 | 59/F | 13 | Gait freezing, dyskinesias |
Levodopa 500mg Cabergoline 1mg Amantadine 100mg Apomorphine 2mg |
10/36 | 11 | Recording done ON medication only. Cluster headache |
4 | 45/F | 8 | Tremor | Ropinirole 27mg | −/50 | 42 | DBS lead only in the right STN. The patient was intolerant of Levodopa so recording done OFF medication only |
5 | 58/F | 14 | Gait freezing, pain, dyskinesias, motor fluctuations |
Levodopa 250mg Pramipexole 4mg |
18/71 | 15* | |
6 | 64/F | 8 | Tremor, dyskinesias |
Levodopa 500mg Ropinirole 17mg Amantadine 300mg Rasagline 1mg |
18/51 | 23# | Recording done ON medication only. Hypothyroidism |
7 | 51/M | 9 | Gait impairment, tremor |
Levodopa 800 mg Rasagiline 1mg |
21/49 | 19$ | REM sleep disorder Previous dopa dysregulation |
8 | 60/M | 15 | Dyskinesias, gait freezing, tremor |
Levodopa 1300mg Ropinirole 18mg Selegiline 10mg Amantadine 200mg |
10/56 | 23 | |
9 | 54/M | 8 | Gait impairment, dyskinesias |
Levodopa 1200mg Cabergoline 4mg Entacapone 800mg Amantadine 300mg |
9/38 | 15# | |
10 | 66/M | 8 | Freezing, motor fluctuations, dyskinesias, tremor |
Levodopa 800mg Pramipexole 2000mg Rasagline 1mg Amantadine 200mg Apomorphine 4-8mg |
18/72 | 21# | Recording done ON medication only |
11 | 48/M | 11 | Gait freezing, tremor |
Levodopa 1250mg Rasagiline 1mg Entacapone 500mg |
16/72 | 25$ | |
12 | 63/F | 9 | Tremor, pain | Rotigotine 4mg Rasagiline 1mg |
−/51 | 12£ | LRRK2 mutation. Patient was intolerant to levodopa, so recording was done OFF medication only. |
13 | 61/M | 9 | Gait freezing, tremor |
Levodopa 1800mg Pramipexole 500micrograms |
5/28 | 19 | |
14 | 58/F | 10 | Dystonia, dyskinesia, motor fluctuations |
Levodopa 450mg Pramipexole 3mg Rasagiline 2mg |
16/55 | 16$ | |
15 | 52/M | 12 | Dystonia | Levodopa 950mg Rotigotine 4mg Rasagiline 1mg |
10/35 | 26 | |
16 | 58/M | 13 | Gait freezing | Levodopa 1200mg Amantadine 400mg Entacapone 600mg Rasagiline 1mg |
25/43 | 17 | |
17 | 57/M | 17 | Gait impairment, pain, dyskinesias |
Levodopa 1550mg Entacapone 1600mg Selegiline 10mg Amantadine 200mg |
14/54 | 32 |
All UPDRS scores OFF medication / ON DBS were assessed at either 6 months (#), 8 months (*), 10 months ($) or 1 year (unmarked). Subject 9 was assessed on Rasagiline 1mg ON DBS (£).