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. Author manuscript; available in PMC: 2007 Jun 15.
Published in final edited form as: Neuroimage. 2006 Dec 16;35(2):467–477. doi: 10.1016/j.neuroimage.2006.12.010

Table 2.

Comparison (means, standard deviations, p values) of (i) white matter lesions (WMLs) versus normal-appearing white matter (NAWM), (ii) remyelinated WMLs (rWMLs) versus NAWM and (iii) demyelinated WMLs (dWMLs) versus rWMLs in post mortem brain of patients with multiple sclerosis

WMLs (n=38) NAWM (n=16) p rWMLs (n=7)a NAWM (n=2)a p dWMLs (n=5) rWMLsb (n=3) p
MD 0.35 (0.09) 0.22 (0.04) <0.01 0.31 (0.07) 0.22 (0.03)  0.01 0.51 (0.12) 0.33 (0.10)  0.06
FA 0.22 (0.06) 0.38 (0.13)  0.01 0.23 (0.07) 0.38 (0.16)  0.01 0.19 (0.05) 0.24 (0.08)  0.17
Trmyelin 0.85 (0.09) 0.45 (0.10) <0.01 0.77 (0.07) 0.43 (0.12) <0.01 0.87 (0.04) 0.80 (0.06) <0.01
Axonal count  8.3 (5.1) 18.7 (2.0) <0.01 11.3 (4.8) 18.9 (2.5)  0.01  3.5 (1.7)  9.2 (0.4)  0.03
Trgliosis 0.76 (0.04) 0.80 (0.03)  0.08 0.75 (0.05) 0.80 (0.02)  0.05 0.76 (0.02) 0.79 (0.03)  0.59

MD=mean diffusivity [×10−3 mm2/s], FA=fractional anisotropy; Trmyelin=transmittance of slides stained for Luxol fast blue; Trgliosis=transmittance of slides immuno-stained for glial fibrillary acidic protein.

a

rWMLs were detected in two cases only.

b

All fully remyelinated (i.e., shadow plaques).