Abstract
The habituation index is a quantitative expression of the ability of the orbicularis oculi (blink reflex) to adapt to a series of electrical stimuli applied to the supraorbital region. This parameter has been studied in a group of normal control subjects, and the results compared with those in cases of idiopathic and drug-induced Parkinsonism, states of dementia, and dyskinesias such as Huntington's chorea and senile chorea. Patients with Huntington's chorea showed a tendency for the reflex to habituate readily in contrast to patients with dementia caused by cortical atrophy and those with Parkinson's disease. Younger patients with Huntington's chorea had indices within the normal range. It seems unlikely that this test will prove of value in the detection of clinically unaffected relatives. Where dementia was associated with a reversible intracranial lesion, the habituation index was studied before and after treatment. Failure of habituation in this condition appears to be due to the release of a primitive protective reflex.
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Selected References
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- Caraceni T., Avanzini G., Spreafico R., Negri S., Broggi G., Girotti F. Study of the excitability cycle of the blink reflex in Huntington's chorea. Eur Neurol. 1976;14(6):465–472. doi: 10.1159/000114774. [DOI] [PubMed] [Google Scholar]
- Esteban A., Giménez-Roldàn S. Blink reflex in Huntingon's chorea and Parkinson's disease. Acta Neurol Scand. 1975 Aug;52(2):145–157. doi: 10.1111/j.1600-0404.1975.tb05768.x. [DOI] [PubMed] [Google Scholar]
- GARLAND H. G. Parkinsonism. Br Med J. 1952 Jan 19;1(4750):153–156. doi: 10.1136/bmj.1.4750.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KUGELBERG E. [Facial reflexes]. Brain. 1952 Sep;75(3):385–396. doi: 10.1093/brain/75.3.385. [DOI] [PubMed] [Google Scholar]
- Klawans H. L., Jr A pharmacologic analysis of Huntington's chorea. Eur Neurol. 1970;4(3):148–163. doi: 10.1159/000114017. [DOI] [PubMed] [Google Scholar]
- Klawans H. L., Jr, Goodwin J. A. Reversal of the glabellar reflex in Parkinsonism by L-dopa. J Neurol Neurosurg Psychiatry. 1969 Oct;32(5):423–427. doi: 10.1136/jnnp.32.5.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Klawans H., Jr, Ilahi M. M., Shenker D. Theoretical implications of the use of L-dopa in parkinsonism. A review. Acta Neurol Scand. 1970;46(4):409–441. doi: 10.1111/j.1600-0404.1970.tb05804.x. [DOI] [PubMed] [Google Scholar]
- Messina C., Di Rosa A. E., Tomasello F. Habituation of blink reflexes in parkinsonian patients under levodopa and amantadine treatment. J Neurol Sci. 1972 Oct;17(2):141–148. doi: 10.1016/0022-510x(72)90136-0. [DOI] [PubMed] [Google Scholar]
- Pearce J., Aziz H., Gallagher J. C. Primitive reflex activity in primary and symptomatic Parkinsonism. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):501–508. doi: 10.1136/jnnp.31.5.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Penders C. A., Delwaide P. J. Blink reflex studies in patients with Parkinsonism before and during therapy. J Neurol Neurosurg Psychiatry. 1971 Dec;34(6):674–678. doi: 10.1136/jnnp.34.6.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thompson R. F., Spencer W. A. Habituation: a model phenomenon for the study of neuronal substrates of behavior. Psychol Rev. 1966 Jan;73(1):16–43. doi: 10.1037/h0022681. [DOI] [PubMed] [Google Scholar]
