Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1975 Feb;50(2):137–141. doi: 10.1136/adc.50.2.137

EB-virus-specific IgM and IgG antibodies in first-degree relatives of children with acute lymphoblastic leukaemia.

H Zorbala-Mallios, R N Sutton, R T Emond
PMCID: PMC1544386  PMID: 165784

Abstract

EB-virus-specific IgM and IgG antibodies (to virus capsid and soluble complement fixing antigens) were estimated in sera from mothers and sibs of children with acute lymphoblastic leukaemia, from patients with infectious mononucleosis, and from control induviduals. IgM antibodies were present in 12 of 16 mothers and 3 of 4 sibs of children with acute lymphoblastic leukaemia. They were also present in 14 of 16 patients with infectious mononucleosis, but in only 1 of 12 control individuals.

Full text

PDF
137

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chandra R. K. Serum immunoglobulin levels in children with acute lymphoblastic leukaemia and their mothers and sibs. Arch Dis Child. 1972 Aug;47(254):618–620. doi: 10.1136/adc.47.254.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Connelly R. R., Christine B. W. A cohort study of cancer following infectious mononucleosis. Cancer Res. 1974 May;34(5):1172–1178. [PubMed] [Google Scholar]
  3. Deardorff W. L., Gerber P., Vogler W. R. Infectious mononucleosis in acute leukemia with rising Epstein-Barr virus antibody titers. Ann Intern Med. 1970 Feb;72(2):235–240. doi: 10.7326/0003-4819-72-2-235. [DOI] [PubMed] [Google Scholar]
  4. Evans A. S., Niederman J. C., McCollum R. W. Seroepidemiologic studies of infectious mononucleosis with EB virus. N Engl J Med. 1968 Nov 21;279(21):1121–1127. doi: 10.1056/NEJM196811212792101. [DOI] [PubMed] [Google Scholar]
  5. Gerber P., Walsh J. H., Rosenblum E. N., Purcell R. H. Association of EB-virus infection with the post-perfusion syndrome. Lancet. 1969 Mar 22;1(7595):593–595. doi: 10.1016/s0140-6736(69)91532-3. [DOI] [PubMed] [Google Scholar]
  6. Golden H. D., Chang R. S., Prescott W., Simpson E., Cooper T. Y. Leukocyte-transforming agent: prolonged excretion by patients with mononucleosis and excretion by normal individuals. J Infect Dis. 1973 Apr;127(4):471–473. doi: 10.1093/infdis/127.4.471. [DOI] [PubMed] [Google Scholar]
  7. Haider S., Coutinho M. de L., Emond R. T., Sutton R. N. Tuberculin anergy and infectious mononucleosis. Lancet. 1973 Jul 14;2(7820):74–74. doi: 10.1016/s0140-6736(73)93265-0. [DOI] [PubMed] [Google Scholar]
  8. Heiniger H. J., Meier H., Kaliss N., Cherry M., Chen H. W., Stoner R. D. Hereditary immunodeficiency and leukemogenesis in HRS-J mice. Cancer Res. 1974 Jan;34(1):201–211. [PubMed] [Google Scholar]
  9. Henle G., Henle W., Diehl V. Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis. Proc Natl Acad Sci U S A. 1968 Jan;59(1):94–101. doi: 10.1073/pnas.59.1.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Holborow E. J., Hemsted E. H., Mead S. V. Smooth muscle autoantibodies in infectious mononucleosis. Br Med J. 1973 Aug 11;3(5875):323–325. doi: 10.1136/bmj.3.5875.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Keast D. Immunosurveillance and cancer. Lancet. 1970 Oct 3;2(7675):710–712. doi: 10.1016/s0140-6736(70)91973-2. [DOI] [PubMed] [Google Scholar]
  12. Lampkin B. C., Canales L., Mauer A. M. Infectious mononucleosis in a child with acute lymphoblastic leukemia. J Pediatr. 1967 Dec;71(6):876–877. doi: 10.1016/s0022-3476(67)80016-7. [DOI] [PubMed] [Google Scholar]
  13. Levine P. H., Stevens D. A., Coccia P. F., Dabich L., Roland A. Infectious mononucleosis prior to acute leukemia: a possible role for the Epstein-Barr virus. Cancer. 1972 Oct;30(4):875–880. doi: 10.1002/1097-0142(197210)30:4<875::aid-cncr2820300402>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  14. Miller G., Niederman J. C., Andrews L. L. Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis. N Engl J Med. 1973 Feb 1;288(5):229–232. doi: 10.1056/NEJM197302012880503. [DOI] [PubMed] [Google Scholar]
  15. Ragab A. H., Vietti T. J. Infectious mononucleosis, lymphoblastic leukemia, and the E. B. virus. Cancer. 1969 Aug;24(2):261–265. doi: 10.1002/1097-0142(196908)24:2<261::aid-cncr2820240208>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  16. Stevens D. A., Levine P. H., Lee S. K., Sonley M. J., Waggoner D. E. Concurrent infectious mononucleosisand acute leukemia. Case reports. Review of theliterature and serologic studies with the herpes-type virus (EB virus). Am J Med. 1971 Feb;50(2):208–217. doi: 10.1016/0002-9343(71)90150-1. [DOI] [PubMed] [Google Scholar]
  17. Stevens D. A., Pry T. W., Manaker R. A. Infectious mononucleosis--always a primary infection with herpes-type virus? J Natl Cancer Inst. 1970 Mar;44(3):533–537. [PubMed] [Google Scholar]
  18. Sutton R. N., Bishun N. P., Soothill J. F. Immunological and chromosomal studies in first-degree relatives of children with acute lymphoblastic leukaemia. Br J Haematol. 1969 Jul;17(1):113–119. doi: 10.1111/j.1365-2141.1969.tb05669.x. [DOI] [PubMed] [Google Scholar]
  19. Sutton R. N., Emond R. T., Thomas D. B., Doniach D. The occurrence of autoantibodies in infectious mononucleosis. Clin Exp Immunol. 1974 Jul;17(3):427–436. [PMC free article] [PubMed] [Google Scholar]
  20. Sutton R. N., Marston S. D., Almond E. J., Emond R. T. Aspects of Epstein-Barr virus infection in childhood. Arch Dis Child. 1974 Feb;49(2):102–106. doi: 10.1136/adc.49.2.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sutton R. N., Marston S. D., Emond R. T. Some observations on complement-fixing antibodies to the EB virus. J Clin Pathol. 1971 Dec;24(9):801–804. doi: 10.1136/jcp.24.9.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sutton R. N., Marston S. D., Pullen H. J., Darby C. W., Emond R. T., Evans D. I. Antibodies to Epstein-Barr and other viruses in children with acute lymphoblastic leukaemia. Arch Dis Child. 1974 Jul;49(7):540–544. doi: 10.1136/adc.49.7.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sutton R. N., Reynolds K., Almond J. P., Marston S. D., Emond R. T. Immunoglobulins and EB virus antibodies in infectious mononucleosis. Clin Exp Immunol. 1973 Mar;13(3):359–366. [PMC free article] [PubMed] [Google Scholar]
  24. Vonka V., Vlcková I., Závadová H., Kouba K., Lazovská J., Duben J. Antibodies to EB virus capsid antigen and to soluble antigen of lymphoblastoid cells in infectious mononucleosis patients. Int J Cancer. 1972 May 15;9(3):529–535. doi: 10.1002/ijc.2910090309. [DOI] [PubMed] [Google Scholar]
  25. Whitehouse J. M., Holborow E. J. Smooth muscle antibody in malignant disease. Br Med J. 1971 Nov 27;4(5786):511–513. doi: 10.1136/bmj.4.5786.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Wollheim F. A., Williams R. C., Jr Studies on the macroglobulins of human serum. I. Polyclonal immunoglobulin class M (IgM) increase in infectious mononucleosis. N Engl J Med. 1966 Jan 13;274(2):61–67. doi: 10.1056/NEJM196601132740202. [DOI] [PubMed] [Google Scholar]
  27. Zorbala-Mallios H., Sutton R. N. E.B.-virus-specific IgM antibodies in first-degree relatives of children with acute lymphoblastic leukaemia. Lancet. 1974 Jan 26;1(7848):119–120. doi: 10.1016/s0140-6736(74)92344-7. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES