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. 1991 Feb;91:49–55. doi: 10.1289/ehp.919149

Lead in bone: sampling and quantitation using K X-rays excited by 109Cd.

D R Chettle 1, M C Scott 1, L J Somervaille 1
PMCID: PMC1519364  PMID: 2040251

Abstract

Lead in bone can be measured in vivo using gamma-rays from a 109Cd source to excite lead K X-rays. Normalization of lead X-ray amplitudes to that of the elastically backscattered 88 keV gamma-rays produces a determination of the concentration of lead in bone mineral that is accurate and insensitive to variations in measurement or bone geometry. For in vivo tibia measurements, a typical precision (1 SD) of +/- 5 micrograms lead (g bone mineral)-1 is achieved for an effective dose equivalent of 2.1 microSv. Measurement can be made of any superficial bone site, but precision will vary approximately as the inverse of the square root of the mass of bone mineral sampled. The apparatus required for this technique is readily transportable, and mobile laboratory facilities are easily established.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahlgren L., Lidén K., Mattsson S., Tejning S. X-ray fluorescence analysis of lead in human skeleton in vivo. Scand J Work Environ Health. 1976 Jun;2(2):82–86. doi: 10.5271/sjweh.2815. [DOI] [PubMed] [Google Scholar]
  2. Ahlgren L., Mattsson S. An X-ray fluorescence technique for in vivo determination of lead concentration in a bone matrix. Phys Med Biol. 1979 Jan;24(1):136–145. doi: 10.1088/0031-9155/24/1/011. [DOI] [PubMed] [Google Scholar]
  3. Chettle D. R., Scott M. C., Somervaille L. J. Improvements in the precision of in vivo bone lead measurements. Phys Med Biol. 1989 Sep;34(9):1295–1300. doi: 10.1088/0031-9155/34/9/014. [DOI] [PubMed] [Google Scholar]
  4. Christoffersson J. O., Schütz A., Ahlgren L., Haeger-Aronsen B., Mattsson S., Skerfving S. Lead in finger-bone analysed in vivo in active and retired lead workers. Am J Ind Med. 1984;6(6):447–457. doi: 10.1002/ajim.4700060608. [DOI] [PubMed] [Google Scholar]
  5. Lindh U., Brune D., Nordberg G. Microprobe analysis of lead in human femur by proton induced X-ray emission (PIXE). Sci Total Environ. 1978 Jul;10(1):31–37. doi: 10.1016/0048-9697(78)90047-5. [DOI] [PubMed] [Google Scholar]
  6. Price J., Baddeley H., Kenardy J. A., Thomas B. J., Thomas B. W. In vivo X-ray fluorescence estimation of bone lead concentrations in Queensland adults. Br J Radiol. 1984 Jan;57(673):29–33. doi: 10.1259/0007-1285-57-673-29. [DOI] [PubMed] [Google Scholar]
  7. Somervaille L. J., Chettle D. R., Scott M. C., Aufderheide A. C., Wallgren J. E., Wittmers L. E., Jr, Rapp G. R., Jr Comparison of two in vitro methods of bone lead analysis and the implications for in vivo measurements. Phys Med Biol. 1986 Nov;31(11):1267–1274. doi: 10.1088/0031-9155/31/11/008. [DOI] [PubMed] [Google Scholar]
  8. Somervaille L. J., Chettle D. R., Scott M. C. In vivo measurement of lead in bone using x-ray fluorescence. Phys Med Biol. 1985 Sep;30(9):929–943. doi: 10.1088/0031-9155/30/9/005. [DOI] [PubMed] [Google Scholar]
  9. Somervaille L. J., Chettle D. R., Scott M. C., Tennant D. R., McKiernan M. J., Skilbeck A., Trethowan W. N. In vivo tibia lead measurements as an index of cumulative exposure in occupationally exposed subjects. Br J Ind Med. 1988 Mar;45(3):174–181. doi: 10.1136/oem.45.3.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Somervaille L. J., Nilsson U., Chettle D. R., Tell I., Scott M. C., Schütz A., Mattsson S., Skerfving S. In vivo measurements of bone lead--a comparison of two x-ray fluorescence techniques used at three different bone sites. Phys Med Biol. 1989 Dec;34(12):1833–1845. doi: 10.1088/0031-9155/34/12/007. [DOI] [PubMed] [Google Scholar]
  11. Wielopolski L., Rosen J. F., Slatkin D. N., Vartsky D., Ellis K. J., Cohn S. H. Feasibility of noninvasive analysis of lead in the human tibia by soft x-ray fluorescence. Med Phys. 1983 Mar-Apr;10(2):248–251. doi: 10.1118/1.595244. [DOI] [PubMed] [Google Scholar]
  12. Wielopolski L., Rosen J. F., Slatkin D. N., Zhang R., Kalef-Ezra J. A., Rothman J. C., Maryanski M., Jenks S. T. In vivo measurement of cortical bone lead using polarized x rays. Med Phys. 1989 Jul-Aug;16(4):521–528. doi: 10.1118/1.596353. [DOI] [PubMed] [Google Scholar]
  13. Wittmers L. E., Jr, Alich A., Aufderheide A. C. Lead in bone. I. Direct analysis for lead in milligram quantities of bone ash by graphite furnace atomic absorption spectroscopy. Am J Clin Pathol. 1981 Jan;75(1):80–85. doi: 10.1093/ajcp/75.1.80. [DOI] [PubMed] [Google Scholar]
  14. Wittmers L. E., Jr, Aufderheide A. C., Wallgren J., Rapp G., Jr, Alich A. Lead in bone. IV. Distribution of lead in the human skeleton. Arch Environ Health. 1988 Nov-Dec;43(6):381–391. doi: 10.1080/00039896.1988.9935855. [DOI] [PubMed] [Google Scholar]

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