Skip to main content
Immunology logoLink to Immunology
. 1978 Jan;34(1):69–75.

Embryonic mouse thymus development: stem cell entry and differentiation.

M A Ritter
PMCID: PMC1457331  PMID: 304838

Abstract

The entry and subsequent division and differentiation of blood-borne stem cells within the embryonic thymus has been studied in a system where the inflowing cells were either chromosomally or antigenically marked. H-2 positive stem cells enter the thymus within 5 days of grafting but may wait for up to 14 days before proliferating to give rise to Thy-1 positive thymocytes.

Full text

PDF
69

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aoki T., Hämmerling U., De Harven E., Boyse E. A., Old L. J. Antigenic structure of cell surfaces. An immunoferritin study of the occurrence and topography of H-2' theta, and TL alloantigens on mouse cells. J Exp Med. 1969 Nov 1;130(5):979–1001. doi: 10.1084/jem.130.5.979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BOYSE E. A., OLD L. J., CHOUROULINKOV I. CYTOTOXIC TEST FOR DEMONSTRATION OF MOUSE ANTIBODY. Methods Med Res. 1964;10:39–47. [PubMed] [Google Scholar]
  3. Basch R. S., Kadish J. L. Hematopoietic thymocyte precursors: II. Properties of the precursors. J Exp Med. 1977 Feb 1;145(2):405–419. doi: 10.1084/jem.145.2.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Boyse E. A., Miyazawa M., Aoki T., Old L. J. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175–193. doi: 10.1098/rspb.1968.0032. [DOI] [PubMed] [Google Scholar]
  5. Cohen A., Schlesinger M. Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells. Transplantation. 1970 Jul;10(1):130–132. doi: 10.1097/00007890-197007000-00027. [DOI] [PubMed] [Google Scholar]
  6. FORD C. E., MICKLEM H. S. The thymus and lymph-nodes in radiation chimaeras. Lancet. 1963 Feb 16;1(7277):359–362. doi: 10.1016/s0140-6736(63)91385-0. [DOI] [PubMed] [Google Scholar]
  7. Kadish J. L., Basch R. S. Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny. J Exp Med. 1976 May 1;143(5):1082–1099. doi: 10.1084/jem.143.5.1082. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Komuro K., Boyse E. A. Induction of T lymphocytes from precursor cells in vitro by a product of the thymus. J Exp Med. 1973 Aug 1;138(2):479–482. doi: 10.1084/jem.138.2.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. METCALF D. THE AUTONOMOUS BEHAVIOUR OF NORMAL THYMUS GRAFTS. Aust J Exp Biol Med Sci. 1963 Aug;41:SUPPL437–SUPPL447. doi: 10.1038/icb.1963.64. [DOI] [PubMed] [Google Scholar]
  10. METCALF D., WAKONIG-VAARTAJA R. STEM CELL REPLACEMENT IN NORMAL THYMUS GRAFTS. Proc Soc Exp Biol Med. 1964 Mar;115:731–735. doi: 10.3181/00379727-115-29022. [DOI] [PubMed] [Google Scholar]
  11. Mandel T. Differentiation of epithelial cells in the mouse thymus. Z Zellforsch Mikrosk Anat. 1970;106(4):498–515. doi: 10.1007/BF00340288. [DOI] [PubMed] [Google Scholar]
  12. Mandi B., Glant T. Thymosin-producing cells of the thymus. Nat New Biol. 1973 Nov 7;246(149):25–25. doi: 10.1038/newbio246025a0. [DOI] [PubMed] [Google Scholar]
  13. Metcalf D. Multiple thymus grafts in aged mice. Nature. 1965 Oct 2;208(5005):87–88. doi: 10.1038/208087a0. [DOI] [PubMed] [Google Scholar]
  14. Moore M. A., Owen J. J. Experimental studies on the development of the thymus. J Exp Med. 1967 Oct 1;126(4):715–726. doi: 10.1084/jem.126.4.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Owen J. J., Raff M. C. Studies on the differentiation of thymus-derived lymphocytes. J Exp Med. 1970 Dec 1;132(6):1216–1232. doi: 10.1084/jem.132.6.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Owen J. J., Ritter M. A. Tissue interaction in the development of thymus lymphocytes. J Exp Med. 1969 Feb 1;129(2):431–442. doi: 10.1084/jem.129.2.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. REIF A. E., ALLEN J. M. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. doi: 10.1084/jem.120.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Reif A. E., Allen J. M. Mouse thymic iso-antigens. Nature. 1966 Jan 29;209(5022):521–523. doi: 10.1038/209521b0. [DOI] [PubMed] [Google Scholar]
  19. Schlesinger M., Hurvitz D. Serological analysis of thymus and spleen grafts. J Exp Med. 1968 Jun 1;127(6):1127–1137. doi: 10.1084/jem.127.6.1127. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES