Abstract
The entry and subsequent division and differentiation of blood-borne stem cells within the embryonic thymus has been studied in a system where the inflowing cells were either chromosomally or antigenically marked. H-2 positive stem cells enter the thymus within 5 days of grafting but may wait for up to 14 days before proliferating to give rise to Thy-1 positive thymocytes.
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Selected References
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- Aoki T., Hämmerling U., De Harven E., Boyse E. A., Old L. J. Antigenic structure of cell surfaces. An immunoferritin study of the occurrence and topography of H-2' theta, and TL alloantigens on mouse cells. J Exp Med. 1969 Nov 1;130(5):979–1001. doi: 10.1084/jem.130.5.979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BOYSE E. A., OLD L. J., CHOUROULINKOV I. CYTOTOXIC TEST FOR DEMONSTRATION OF MOUSE ANTIBODY. Methods Med Res. 1964;10:39–47. [PubMed] [Google Scholar]
- Basch R. S., Kadish J. L. Hematopoietic thymocyte precursors: II. Properties of the precursors. J Exp Med. 1977 Feb 1;145(2):405–419. doi: 10.1084/jem.145.2.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Boyse E. A., Miyazawa M., Aoki T., Old L. J. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175–193. doi: 10.1098/rspb.1968.0032. [DOI] [PubMed] [Google Scholar]
- Cohen A., Schlesinger M. Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells. Transplantation. 1970 Jul;10(1):130–132. doi: 10.1097/00007890-197007000-00027. [DOI] [PubMed] [Google Scholar]
- FORD C. E., MICKLEM H. S. The thymus and lymph-nodes in radiation chimaeras. Lancet. 1963 Feb 16;1(7277):359–362. doi: 10.1016/s0140-6736(63)91385-0. [DOI] [PubMed] [Google Scholar]
- Kadish J. L., Basch R. S. Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny. J Exp Med. 1976 May 1;143(5):1082–1099. doi: 10.1084/jem.143.5.1082. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Komuro K., Boyse E. A. Induction of T lymphocytes from precursor cells in vitro by a product of the thymus. J Exp Med. 1973 Aug 1;138(2):479–482. doi: 10.1084/jem.138.2.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
- METCALF D. THE AUTONOMOUS BEHAVIOUR OF NORMAL THYMUS GRAFTS. Aust J Exp Biol Med Sci. 1963 Aug;41:SUPPL437–SUPPL447. doi: 10.1038/icb.1963.64. [DOI] [PubMed] [Google Scholar]
- METCALF D., WAKONIG-VAARTAJA R. STEM CELL REPLACEMENT IN NORMAL THYMUS GRAFTS. Proc Soc Exp Biol Med. 1964 Mar;115:731–735. doi: 10.3181/00379727-115-29022. [DOI] [PubMed] [Google Scholar]
- Mandel T. Differentiation of epithelial cells in the mouse thymus. Z Zellforsch Mikrosk Anat. 1970;106(4):498–515. doi: 10.1007/BF00340288. [DOI] [PubMed] [Google Scholar]
- Mandi B., Glant T. Thymosin-producing cells of the thymus. Nat New Biol. 1973 Nov 7;246(149):25–25. doi: 10.1038/newbio246025a0. [DOI] [PubMed] [Google Scholar]
- Metcalf D. Multiple thymus grafts in aged mice. Nature. 1965 Oct 2;208(5005):87–88. doi: 10.1038/208087a0. [DOI] [PubMed] [Google Scholar]
- Moore M. A., Owen J. J. Experimental studies on the development of the thymus. J Exp Med. 1967 Oct 1;126(4):715–726. doi: 10.1084/jem.126.4.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Owen J. J., Raff M. C. Studies on the differentiation of thymus-derived lymphocytes. J Exp Med. 1970 Dec 1;132(6):1216–1232. doi: 10.1084/jem.132.6.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Owen J. J., Ritter M. A. Tissue interaction in the development of thymus lymphocytes. J Exp Med. 1969 Feb 1;129(2):431–442. doi: 10.1084/jem.129.2.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
- REIF A. E., ALLEN J. M. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. doi: 10.1084/jem.120.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reif A. E., Allen J. M. Mouse thymic iso-antigens. Nature. 1966 Jan 29;209(5022):521–523. doi: 10.1038/209521b0. [DOI] [PubMed] [Google Scholar]
- Schlesinger M., Hurvitz D. Serological analysis of thymus and spleen grafts. J Exp Med. 1968 Jun 1;127(6):1127–1137. doi: 10.1084/jem.127.6.1127. [DOI] [PMC free article] [PubMed] [Google Scholar]
