Abstract
The beneficial effects in humans of ingesting fish oils have attracted much attention among medical scientists and nutritionists recently. Human studies conducted in populations of Eskimos, Japanese, and Caucasians since 1970 are reviewed in this paper. The evidence shows that a diet rich in omega-3 fatty acids significantly reduces plasma cholesterol and triglyceride levels, improves fat tolerance, prolongs bleeding times, reduces platelet counts, and decreases platelet adhesiveness.
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Selected References
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- Bang H. O., Dyerberg J., Hjøorne N. The composition of food consumed by Greenland Eskimos. Acta Med Scand. 1976;200(1-2):69–73. doi: 10.1111/j.0954-6820.1976.tb08198.x. [DOI] [PubMed] [Google Scholar]
- Bang H. O., Dyerberg J. Plasma lipids and lipoproteins in Greenlandic west coast Eskimos. Acta Med Scand. 1972 Jul-Aug;192(1-2):85–94. doi: 10.1111/j.0954-6820.1972.tb04782.x. [DOI] [PubMed] [Google Scholar]
- Bang H. O., Dyerberg J., Sinclair H. M. The composition of the Eskimo food in north western Greenland. Am J Clin Nutr. 1980 Dec;33(12):2657–2661. doi: 10.1093/ajcn/33.12.2657. [DOI] [PubMed] [Google Scholar]
- Bang H. O., Dyerberg J. The bleeding tendency in Greenland Eskimos. Dan Med Bull. 1980 Sep;27(4):202–205. [PubMed] [Google Scholar]
- Cartwright I. J., Pockley A. G., Galloway J. H., Greaves M., Preston F. E. The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. Atherosclerosis. 1985 Jun;55(3):267–281. doi: 10.1016/0021-9150(85)90106-6. [DOI] [PubMed] [Google Scholar]
- Chiba K., Koizumi A., Kumai M., Watanabe T., Ikeda M. Nationwide survey of high-density lipoprotein cholesterol among farmers in Japan. Prev Med. 1983 Jul;12(4):508–522. doi: 10.1016/0091-7435(83)90205-0. [DOI] [PubMed] [Google Scholar]
- Dyerberg J., Bang H. O. Dietary fat and thrombosis. Lancet. 1978 Jan 21;1(8056):152–152. doi: 10.1016/s0140-6736(78)90448-8. [DOI] [PubMed] [Google Scholar]
- Dyerberg J., Bang H. O. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet. 1979 Sep 1;2(8140):433–435. doi: 10.1016/s0140-6736(79)91490-9. [DOI] [PubMed] [Google Scholar]
- Dyerberg J., Bang H. O., Hjorne N. Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr. 1975 Sep;28(9):958–966. doi: 10.1093/ajcn/28.9.958. [DOI] [PubMed] [Google Scholar]
- Dyerberg J., Bang H. O., Hjorne N. Plasma cholesterol concentration in Caucasian Danes and Greenland West-coast Eskimos. Dan Med Bull. 1977 Apr;24(2):52–55. [PubMed] [Google Scholar]
- Dyerberg J., Jørgensen K. A. Marine oils and thrombogenesis. Prog Lipid Res. 1982;21(4):255–269. doi: 10.1016/0163-7827(82)90011-x. [DOI] [PubMed] [Google Scholar]
- Dyerberg J. Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. Nutr Rev. 1986 Apr;44(4):125–134. doi: 10.1111/j.1753-4887.1986.tb07603.x. [DOI] [PubMed] [Google Scholar]
- Dyerberg J. Platelet - vessel wall interaction: influence of diet. Philos Trans R Soc Lond B Biol Sci. 1981 Aug 18;294(1072):373–381. doi: 10.1098/rstb.1981.0113. [DOI] [PubMed] [Google Scholar]
- Galloway J. H., Cartwright I. J., Woodcock B. E., Greaves M., Russell R. G., Preston F. E. Effects of dietary fish oil supplementation on the fatty acid composition of the human platelet membrane: demonstration of selectivity in the incorporation of eicosapentaenoic acid into membrane phospholipid pools. Clin Sci (Lond) 1985 Apr;68(4):449–454. doi: 10.1042/cs0680449. [DOI] [PubMed] [Google Scholar]
- Glomset J. A. Fish, fatty acids, and human health. N Engl J Med. 1985 May 9;312(19):1253–1254. doi: 10.1056/NEJM198505093121909. [DOI] [PubMed] [Google Scholar]
- Goodnight S. H., Jr, Harris W. S., Connor W. E. The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study. Blood. 1981 Nov;58(5):880–885. [PubMed] [Google Scholar]
- Green D., Barreres L., Borensztajn J., Kaplan P., Reddy M. N., Rovner R., Simon H. A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. Stroke. 1985 Jul-Aug;16(4):706–709. doi: 10.1161/01.str.16.4.706. [DOI] [PubMed] [Google Scholar]
- Harris W. S., Connor W. E., Goodnight S. H., Jr Dietary fish oils, plasma lipids and platelets in man. Prog Lipid Res. 1981;20:75–79. doi: 10.1016/0163-7827(81)90016-3. [DOI] [PubMed] [Google Scholar]
- Harris W. S., Connor W. E., Inkeles S. B., Illingworth D. R. Dietary omega-3 fatty acids prevent carbohydrate-induced hypertriglyceridemia. Metabolism. 1984 Nov;33(11):1016–1019. doi: 10.1016/0026-0495(84)90230-0. [DOI] [PubMed] [Google Scholar]
- Harris W. S., Connor W. E., McMurry M. P. The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils. Metabolism. 1983 Feb;32(2):179–184. doi: 10.1016/0026-0495(83)90226-3. [DOI] [PubMed] [Google Scholar]
- Hirai A., Terano T., Hamazaki T., Sajiki J., Kondo S., Ozawa A., Fujita T., Miyamoto T., Tamura Y., Kumagai A. The effects of the oral administration of fish oil concentrate on the release and the metabolism of [14C]arachidonic acid and [14C]eicosapentaenoic acid by human platelets. Thromb Res. 1982 Nov 1;28(3):285–298. doi: 10.1016/0049-3848(82)90112-8. [DOI] [PubMed] [Google Scholar]
- Kagawa Y. Impact of Westernization on the nutrition of Japanese: changes in physique, cancer, longevity and centenarians. Prev Med. 1978 Jun;7(2):205–217. doi: 10.1016/0091-7435(78)90246-3. [DOI] [PubMed] [Google Scholar]
- Kagawa Y., Nishizawa M., Suzuki M., Miyatake T., Hamamoto T., Goto K., Motonaga E., Izumikawa H., Hirata H., Ebihara A. Eicosapolyenoic acids of serum lipids of Japanese islanders with low incidence of cardiovascular diseases. J Nutr Sci Vitaminol (Tokyo) 1982;28(4):441–453. doi: 10.3177/jnsv.28.441. [DOI] [PubMed] [Google Scholar]
- Kimura N. Changing patterns of coronary heart disease, stroke, and nutrient intake in Japan. Prev Med. 1983 Jan;12(1):222–227. doi: 10.1016/0091-7435(83)90198-6. [DOI] [PubMed] [Google Scholar]
- Kobayashi S., Hirai A., Terano T., Hamazaki T., Tamura Y., Kumagai A. Reduction in blood viscosity by eicosapentaenoic acid. Lancet. 1981 Jul 25;2(8239):197–197. doi: 10.1016/s0140-6736(81)90373-1. [DOI] [PubMed] [Google Scholar]
- Kromhout D., Bosschieter E. B., de Lezenne Coulander C. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med. 1985 May 9;312(19):1205–1209. doi: 10.1056/NEJM198505093121901. [DOI] [PubMed] [Google Scholar]
- LOVERN J. A. The nutritional significance of fish lipids. Proc Nutr Soc. 1958;17(2):161–166. doi: 10.1079/pns19580032. [DOI] [PubMed] [Google Scholar]
- Lee T. H., Hoover R. L., Williams J. D., Sperling R. I., Ravalese J., 3rd, Spur B. W., Robinson D. R., Corey E. J., Lewis R. A., Austen K. F. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med. 1985 May 9;312(19):1217–1224. doi: 10.1056/NEJM198505093121903. [DOI] [PubMed] [Google Scholar]
- Nestel P. J., Connor W. E., Reardon M. F., Connor S., Wong S., Boston R. Suppression by diets rich in fish oil of very low density lipoprotein production in man. J Clin Invest. 1984 Jul;74(1):82–89. doi: 10.1172/JCI111422. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Phillipson B. E., Rothrock D. W., Connor W. E., Harris W. S., Illingworth D. R. Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. N Engl J Med. 1985 May 9;312(19):1210–1216. doi: 10.1056/NEJM198505093121902. [DOI] [PubMed] [Google Scholar]
- Prescott S. M., Zimmerman G. A., Morrison A. R. The effects of a diet rich in fish oil on human neutrophils: identification of leukotriene B5 as a metabolite. Prostaglandins. 1985 Aug;30(2):209–227. doi: 10.1016/0090-6980(85)90186-8. [DOI] [PubMed] [Google Scholar]
- Sanders T. A., Sullivan D. R., Reeve J., Thompson G. R. Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia. Arteriosclerosis. 1985 Sep-Oct;5(5):459–465. doi: 10.1161/01.atv.5.5.459. [DOI] [PubMed] [Google Scholar]
- Sanders T. A., Vickers M., Haines A. P. Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. Clin Sci (Lond) 1981 Sep;61(3):317–324. doi: 10.1042/cs0610317. [DOI] [PubMed] [Google Scholar]
- Siess W., Roth P., Scherer B., Kurzmann I., Böhlig B., Weber P. C. Platelet-membrane fatty acids, platelet aggregation, and thromboxane formation during a mackerel diet. Lancet. 1980 Mar 1;1(8166):441–444. doi: 10.1016/s0140-6736(80)90995-2. [DOI] [PubMed] [Google Scholar]
- Stansby M. E. Nutritional properties of fish oils. World Rev Nutr Diet. 1969;11:46–105. doi: 10.1159/000387575. [DOI] [PubMed] [Google Scholar]
- von Lossonczy T. O., Ruiter A., Bronsgeest-Schoute H. C., van Gent C. M., Hermus R. J. The effect of a fish diet on serum lipids in healthy human subjects. Am J Clin Nutr. 1978 Aug;31(8):1340–1346. doi: 10.1093/ajcn/31.8.1340. [DOI] [PubMed] [Google Scholar]
- von Schacky C., Siess W., Fischer S., Weber P. C. A comparative study of eicosapentaenoic acid metabolism by human platelets in vivo and in vitro. J Lipid Res. 1985 Apr;26(4):457–464. [PubMed] [Google Scholar]
