| 1964 | John Eager Howard, MD. Urinary Stone. |
| 1965 | Grant W. Liddle, MD. Analyse Circadian Rhythms of Adrenal Secretions. |
| 1966 | John P. Merrill, MD. What Can We Do for the Patient with Renal Failure? |
| 1967 | Steward Wolf, MD. Neural Mechanisms in Sudden Cardiac Death. |
| 1968 | Robert W. Wilkins, MD. Clinical and Climatological Observations of Hypertension. |
| 1969 | James B. Wyngaarden, MD. The Pathophysiology of Hyperuricemia in Gout. |
| 1970 | A. McGehee Harvey, MD. Myasthenia Gravis—The First 100 Years of Perspective. |
| 1971 | Marvin D. Siperstein, MD, PhD. The Relationship of Cholesterol Bio-synthesis to Cancer. |
| 1972 | George F. Cahill, Jr., MD. Ketosis. |
| 1973 | Richard B. Hornick, MD. Salmonella Infections—Newer Perspectives of an Old Infection. |
| 1974 | Jacques Genest, MD. The Renin-Angiotensin System. |
| 1975 | Victor A. McKusick, MD. New Genetic Insight into Old Diseases. |
| 1976 | Robert M. Bird, MD. Information Transfer in the Service of Medicine. |
| 1977 | Robert Austrian, MD. Gold and Pneumococci. |
| 1978 | Carl W. Gottschalk, MD. The Nephrons in Bright's Disease: Their Structure and Function. |
| 1979 | Sheldon M. Wolff, MD. The Pathogenesis of Fever in Human Subjects. |
| 1980 | Charles C. J. Carpenter, MD. Myths, Mandarins and Molecules: The Cautionary Tale of Cholera. |
| 1981 | Leighton E. Cluff, MD. The Climate of Patient Care and Medical Education. |
| 1982 | Daniel D. Federman, MD. The Determinants of Human Sexuality. |
| 1983 | Purnell W. Choppin, MD. Membrane Proteins and Virus Virulence. |
| 1984 | Jack M. Gwaltney, Jr., MD. Climatology and the Common Cold. |
| 1985 | Louis Tobian, MD. High Potassium Diets Strongly Protect Against Stroke Deaths and Renal Disease: A Possible Legacy from Prehistoric Man. |
| 1986 | Richard S. Ross, MD. Thrombolysis and Dilatation in Coronary Occlusion. |
| 1987 | William N. Kelley, MD, and Thomas D. Palella, MD. Current Status of Human Gene Therapy. |
| 1988 | John A. Oates, MD. Participation of Eicosanoids in the Syndromes of Myocardial Ischemia. |
| 1989 | David G. Nathan, MD. The Regulation of Hematopoiesis by Growth Factors. |
| 1990 | Michel Chrétien, O.C., MD. From POMC to Functional Diversity of Neural Peptides: The Key Importance of Convertases. |
| 1991 | Gerald L. Mandell, MD. Microbial Defenses Against Killing by Phagocytes. |
| 1992 | Jeremiah A. Barondess, MD. The Future of Generalism. |
| 1993 | John D. Stobo, MD. Academic Health Centers: Change Agents for Health Care Reform. |
| 1994 | J. Claude Bennett, MD. Academic Medicine: Building on the Strengths of the Past as We Approach a Cloudy Future. |
| 1995 | Stuart Bondurant, MD. On the Climate of the City. |
| 1996 | Edward W. Hook, MD. Humanities in Medicine: Treatment of a Deficiency Disorder. |
| 1997 | R. Gordon Douglas, Jr., MD. Vaccine Prophylaxis Today: It's Science, Application and Politics. |
| 1998 | James R. Gavin, III. Academe Confronts a Future of Growing Diversity: Will We Lead or Will We Follow? |
| 1999 | John Mendelsohn, MD. Targeted Cancer Therapy. |
| 2000 | Ralph L. Nachman, MD. Hypercoagulable States: Challenges and Opportunities. |
| 2001 | Jared J. Grantham, MD. Polycystic Kidney Disease: Old Disease in a New Context. |
| 2002 | R. Wayne Alexander, MD, PhD. Pathogenesis of Atherosclerosis: Redox As a Unifying Mechanism. |
| 2003 | Merle A. Sande, MD, MACP. The Terrible Impact of AIDS on Africa—The Case for Prevention & Treatment Now. |
| 2004 | C. Richard Conti, MD. The Evolution of Management of Acute Coronary Syndromes. |
| 2005 | John G. Bartlett, MD. Avian Influenza. |
| 2006 | James A. Fagan, MD. Intelligent Design of Cancer Therapy: Trials and Tribulations. |
| 2007 | Stephen B. Greenberg. Osler-Web-Rendezvous: Impact of the Information Explosion on Medical Education. |
| 2008 | Katherine A. High, MD. Gene Therapy for Inherited Disorders: From Christmas Disease to Leber's Amaurosis. |
| 2009 | Eric G. Neilson, MD. The Origin of Fibroblasts and the Terminality of Epithelial Differentiation. |
| 2010 | Antonio M. Gotto, MD. Cholesterol, Inflammation and Cardiovascular Disease: Is It All LDL? |
| 2011 | Martin JL. Blaser, MD. Global Warming Redux: The Disappearing Microbiota and Epidemic Obesity. |
| 2012 | Nancy J. Brown, MD. Developing Physician-Scientists: A perspective. |
| 2013 | Christopher Plowe, MD. New Additions to the Toolbox for Glosbal Malaria Eradication. |
| 2014 | Raymond N. Dubois, MD, PhD. Inflammation, Immune Modulators and Chronic Disease. |
| 2015 | Anne A. Gershon, MD, and Michael D. Gershon, MD. Varicella Zoster Virus: From Outside to Inside. |
| 2016 | Edward J. Benz, Jr., MD. Cancer in the Twenty-First Century: An Inside View From an Outsider. |
| 2017 | Ronald Crystal, MD. Novel Therapeutic Strategies for Allergic Disorders. |
| 2018 | Allen Spiegel, MD. A Brief History of Eugenics in America: Implications for Medicine in the 21st Century. |
| 2019 | Joseph Fins, MD. Disorders of Consciousness & the Normative Uncertainty of an Emerging Nosology. |
| 2022 | William G. Kaelin, Jr., MD. von Hippel-Lindau Disease: Insights into Oxygen Sensing, Cancer and Drugging the Undruggable. |
| 2022 | Katherine A. High, MD. Turning Genes Into Medicines: Highlights and Hurdles in the Development of Gene Therapy for Genetic Disease. |
. 2023;133:201–203.