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. 1969 Jun;63(2):512–519. doi: 10.1073/pnas.63.2.512

ON THE MECHANISM OF ACTION OF ADRENOCORTICOTROPIC HORMONE: THE BINDING OF CYCLIC-3′,5′-ADENOSINE MONOPHOSPHATE TO AN ADRENAL CORTICAL PROTEIN*

Gordon N Gill 1,†,‡, Leonard D Garren 1,‡
PMCID: PMC223593  PMID: 4308274

Abstract

The binding of cyclic 3′,5′-adenosine monophosphate (cyclic AMP) within the adrenal cortical cell was studied. Cyclic AMP binds specifically to a protein which is associated predominantly with the microsomal fraction of the cell.

The binding protein was purified approximately 100-fold.

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Selected References

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