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. 1974 Oct;71(10):3863–3865. doi: 10.1073/pnas.71.10.3863

Solutions to the Cost-of-Selection Dilemma

Verne Grant 1,2, Robert H Flake 1,2
PMCID: PMC434284  PMID: 4530266

Abstract

There are various biologically realistic ways around the cost-of-selection restriction on rapid multiple-gene substitution. Some of these ways depend upon particular forms of interaction or linkage in the genes undergoing substitution; other ways depend on particular conditions of population size and structure. The special genotypic and populational conditions required for rapid evolutionary change in genetically complex characters are not unusual in higher organisms.

Keywords: substitutional load, gene substitution, evolutionary rate

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allard R. W., Babbel G. R., Clegg M. T., Kahler A. L. Evidence for coadaptation in Avena barbata. Proc Natl Acad Sci U S A. 1972 Oct;69(10):3043–3048. doi: 10.1073/pnas.69.10.3043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ayala F. J., Anderson W. W. Evidence of natural selection in molecular evolution. Nat New Biol. 1973 Feb 28;241(113):274–276. doi: 10.1038/newbio241274a0. [DOI] [PubMed] [Google Scholar]
  3. Ayala F. J., Tracey M. L. Genetic differentiation within and between species of the Drosophila willistoni group. Proc Natl Acad Sci U S A. 1974 Mar;71(3):999–1003. doi: 10.1073/pnas.71.3.999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brues A. M. Genetic load and its varieties. Science. 1969 Jun 6;164(3884):1130–1136. doi: 10.1126/science.164.3884.1130. [DOI] [PubMed] [Google Scholar]
  5. Clarke B. Darwinian evolution of proteins. Science. 1970 May 22;168(3934):1009–1011. doi: 10.1126/science.168.3934.1009. [DOI] [PubMed] [Google Scholar]
  6. Clegg M. T., Allard R. W. Patterns of Genetic Differentiation in the Slender Wild Oat Species Avena barbata. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1820–1824. doi: 10.1073/pnas.69.7.1820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Flake R. H., Grant V. An analysis of the cost-of-selection concept. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3716–3720. doi: 10.1073/pnas.71.9.3716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Grant V., Flake R. H. Population structure in relation to cost of selection. Proc Natl Acad Sci U S A. 1974 May;71(5):1670–1671. doi: 10.1073/pnas.71.5.1670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Johnson G. B. Enzyme polymorphism and metabolism. Science. 1974 Apr 5;184(4132):28–37. doi: 10.1126/science.184.4132.28. [DOI] [PubMed] [Google Scholar]
  10. Kimura M., Crow J. F. Natural selection and gene substitution. Genet Res. 1969 Apr;13(2):127–141. doi: 10.1017/s0016672300002846. [DOI] [PubMed] [Google Scholar]
  11. Kimura M. Evolutionary rate at the molecular level. Nature. 1968 Feb 17;217(5129):624–626. doi: 10.1038/217624a0. [DOI] [PubMed] [Google Scholar]
  12. Kimura M., Maruyama T. The substitutional load in a finite population. Heredity (Edinb) 1969 Feb;24(1):101–114. doi: 10.1038/hdy.1969.10. [DOI] [PubMed] [Google Scholar]
  13. King J. L. Continuously distributed factors affecting fitness. Genetics. 1967 Mar;55(3):483–492. doi: 10.1093/genetics/55.3.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. King J. L. The gene interaction component of the genetic load. Genetics. 1966 Mar;53(3):403–413. doi: 10.1093/genetics/53.3.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kojima K. The distribution and comparison of "genetic loads" under heterotic selection and simple frequency-dependent selection in finite populations. Theor Popul Biol. 1971 Jun;2(2):159–173. doi: 10.1016/0040-5809(71)90013-x. [DOI] [PubMed] [Google Scholar]
  16. Kojima K., Yarbrough K. M. FREQUENCY-DEPENDENT SELECTION AT THE ESTERASE 6 LOCUS IN Drosophila melanogaster. Proc Natl Acad Sci U S A. 1967 Mar;57(3):645–649. doi: 10.1073/pnas.57.3.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Lewontin R. C., Hubby J. L. A molecular approach to the study of genic heterozygosity in natural populations. II. Amount of variation and degree of heterozygosity in natural populations of Drosophila pseudoobscura. Genetics. 1966 Aug;54(2):595–609. doi: 10.1093/genetics/54.2.595. [DOI] [PMC free article] [PubMed] [Google Scholar]

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