Abstract
Two patients on long-term lithium therapy for manic-depressive psychosis developed serious toxicity within days of being prescribed a combination of triamterene (50 mg) and hydrochlorothiazide (25 mg) for mild symptomless hypertension. Reduced clearance of lithium has been reported to follow its concurrent administration with diuretics that deplete both sodium and potassium. A combination of triamterene with thiazide has not been shown previously to precipitate lithium toxicity.
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Selected References
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- Gaind R., Sarand B. M. Treatment of acute lithium intoxication. Lancet. 1970 Jan 24;1(7639):197–198. doi: 10.1016/s0140-6736(70)90451-4. [DOI] [PubMed] [Google Scholar]
- Himmelhoch J. M., Forrest J., Neil J. F., Detre T. P. Thiazide-lithium synergy in refractory mood swings. Am J Psychiatry. 1977 Feb;134(2):149–152. doi: 10.1176/ajp.134.2.149. [DOI] [PubMed] [Google Scholar]
- Macfie A. C. Letter: Lithium poisoning precipitated by diuretics. Br Med J. 1975 Mar 1;1(5956):516–516. doi: 10.1136/bmj.1.5956.516-d. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Petersen V., Hvidt S., Thomsen K., Schou M. Effect of prolonged thiazide treatment on renal lithium clearance. Br Med J. 1974 Jul 20;3(5924):143–145. doi: 10.1136/bmj.3.5924.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weinstein M. R., Goldfield M. D., Wilbanks G. D. Lithium ion toxicity and pregnancy. JAMA. 1970 Nov 16;214(7):1325–1326. [PubMed] [Google Scholar]