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. 1995 Sep;63(9):3697–3701. doi: 10.1128/iai.63.9.3697-3701.1995

Decomplementation by cobra venom factor suppresses Yersinia-induced arthritis in rats.

K I Gaede 1, E Baumeister 1, J Heesemann 1
PMCID: PMC173512  PMID: 7642308

Abstract

Lewis rats experimentally infected with Yersinia enterocolitica O8 develop Yersinia-induced arthritis (YIA), which resembles very much reactive arthritis in humans. To investigate the involvement of serum complement in induction and maintenance of YIA, we decomplementated Yersinia-infected Lewis rats by treatment with cobra venom factor starting on day 7 after infection (prearthritic state). Reduction of serum complement activity in vivo by cobra venom factor treatment coincided with suppression of YIA clinically and histomorphologically.

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Selected References

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  1. Ahvonen P., Sievers K., Aho K. Arthritis associated with Yersinia enterocolitica infection. Acta Rheumatol Scand. 1969;15(3):232–253. doi: 10.3109/rhe1.1969.15.issue-1-4.32. [DOI] [PubMed] [Google Scholar]
  2. China B., Sory M. P., N'Guyen B. T., De Bruyere M., Cornelis G. R. Role of the YadA protein in prevention of opsonization of Yersinia enterocolitica by C3b molecules. Infect Immun. 1993 Aug;61(8):3129–3136. doi: 10.1128/iai.61.8.3129-3136.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cochrane C. G., Müller-Eberhard H. J., Aikin B. S. Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions. J Immunol. 1970 Jul;105(1):55–69. [PubMed] [Google Scholar]
  4. Ford D. K., da Roza D., Schulzer M. Lymphocytes from the site of disease but not blood lymphocytes indicate the cause of arthritis. Ann Rheum Dis. 1985 Oct;44(10):701–710. doi: 10.1136/ard.44.10.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Frank M. M., Fries L. F. The role of complement in inflammation and phagocytosis. Immunol Today. 1991 Sep;12(9):322–326. doi: 10.1016/0167-5699(91)90009-I. [DOI] [PubMed] [Google Scholar]
  6. Gaede K. I., Heesemann J. Arthritogenicity of genetically manipulated Yersinia enterocolitica serotype O8 for Lewis rats. Infect Immun. 1995 Feb;63(2):714–719. doi: 10.1128/iai.63.2.714-719.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gaede K., Mack D., Heesemann J. Experimental Yersinia enterocolitica infection in rats: analysis of the immune response to plasmid-encoded antigens of arthritis-susceptible Lewis rats and arthritis-resistant Fischer rats. Med Microbiol Immunol. 1992;181(3):165–172. doi: 10.1007/BF00202056. [DOI] [PubMed] [Google Scholar]
  8. Gaston J. S., Life P. F., Bailey L. C., Bacon P. A. In vitro responses to a 65-kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients. J Immunol. 1989 Oct 15;143(8):2494–2500. [PubMed] [Google Scholar]
  9. Granfors K., Jalkanen S., von Essen R., Lahesmaa-Rantala R., Isomäki O., Pekkola-Heino K., Merilahti-Palo R., Saario R., Isomäki H., Toivanen A. Yersinia antigens in synovial-fluid cells from patients with reactive arthritis. N Engl J Med. 1989 Jan 26;320(4):216–221. doi: 10.1056/NEJM198901263200404. [DOI] [PubMed] [Google Scholar]
  10. Granfors K., Lahesmaa-Rantala K., Toivanen A. IgM, IgG, and IgA antibodies in Yersinia infection. J Infect Dis. 1988 Mar;157(3):601–602. doi: 10.1093/infdis/157.3.601. [DOI] [PubMed] [Google Scholar]
  11. Granfors K., Viljanen M., Tiilikainen A., Toivanen A. Persistence of IgM, IgG, and IgA antibodies to Yersinia in yersinia arthritis. J Infect Dis. 1980 Apr;141(4):424–429. doi: 10.1093/infdis/141.4.424. [DOI] [PubMed] [Google Scholar]
  12. Gripenberg-Lerche C., Skurnik M., Zhang L., Söderström K. O., Toivanen P. Role of YadA in arthritogenicity of Yersinia enterocolitica serotype O:8: experimental studies with rats. Infect Immun. 1994 Dec;62(12):5568–5575. doi: 10.1128/iai.62.12.5568-5575.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hammer M., Zeidler H., Klimsa S., Heesemann J. Yersinia enterocolitica in the synovial membrane of patients with Yersinia-induced arthritis. Arthritis Rheum. 1990 Dec;33(12):1795–1800. doi: 10.1002/art.1780331206. [DOI] [PubMed] [Google Scholar]
  14. Hanski C., Naumann M., Grützkau A., Pluschke G., Friedrich B., Hahn H., Riecken E. O. Humoral and cellular defense against intestinal murine infection with Yersinia enterocolitica. Infect Immun. 1991 Mar;59(3):1106–1111. doi: 10.1128/iai.59.3.1106-1111.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Heesemann J., Gaede K., Autenrieth I. B. Experimental Yersinia enterocolitica infection in rodents: a model for human yersiniosis. APMIS. 1993 Jun;101(6):417–429. [PubMed] [Google Scholar]
  16. Hermann E., Fleischer B., Mayet W. J., Poralla T., Meyer zum Büschenfelde K. H. Response of synovial fluid T cell clones to Yersinia enterocolitica antigens in patients with reactive Yersinia arthritis. Clin Exp Immunol. 1989 Mar;75(3):365–370. [PMC free article] [PubMed] [Google Scholar]
  17. Hermann E., Mayet W. J., Lohse A. W., Grevenstein J., Meyer zum Büschenfelde K. H., Fleischer B. Proliferative response of synovial fluid and peripheral blood mononuclear cells to arthritogenic and non-arthritogenic microbial antigens and to the 65-kDa mycobacterial heat-shock protein. Med Microbiol Immunol. 1990;179(4):215–224. doi: 10.1007/BF00195252. [DOI] [PubMed] [Google Scholar]
  18. Hill J. L., Yu D. T. Development of an experimental animal model for reactive arthritis induced by Yersinia enterocolitica infection. Infect Immun. 1987 Mar;55(3):721–726. doi: 10.1128/iai.55.3.721-726.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Koga T., Kakimoto K., Hirofuji T., Kotani S., Ohkuni H., Watanabe K., Okada N., Okada H., Sumiyoshi A., Saisho K. Acute joint inflammation in mice after systemic injection of the cell wall, its peptidoglycan, and chemically defined peptidoglycan subunits from various bacteria. Infect Immun. 1985 Oct;50(1):27–34. doi: 10.1128/iai.50.1.27-34.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Kosunen T. U., Kauranen O., Martio J., Pitkänen T., Pönkä A., Hortling L., Aittoniemi S., Mutru O., Penttilä O., Koskimies S. Reactive arthritis after campylobacter jejuni enteritis in patients with HLA-B27. Lancet. 1980 Jun 14;1(8181):1312–1313. doi: 10.1016/s0140-6736(80)91776-6. [DOI] [PubMed] [Google Scholar]
  21. Lahesmaa-Rantala R., Granfors K., Isomäki H., Toivanen A. Yersinia specific immune complexes in the synovial fluid of patients with yersinia triggered reactive arthritis. Ann Rheum Dis. 1987 Jul;46(7):510–514. doi: 10.1136/ard.46.7.510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Lahesmaa-Rantala R., Granfors K., Kekomäki R., Toivanen A. Circulating yersinia specific immune complexes after acute yersiniosis: a follow up study of patients with and without reactive arthritis. Ann Rheum Dis. 1987 Feb;46(2):121–126. doi: 10.1136/ard.46.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Larsen J. H., Hartzen S. H., Parm M. The determination of specific IgA-antibodies to Yersinia enterocolitica and their role in enteric infections and their complications. Acta Pathol Microbiol Immunol Scand B. 1985 Oct;93(5):331–339. doi: 10.1111/j.1699-0463.1985.tb02897.x. [DOI] [PubMed] [Google Scholar]
  24. Lauhio A., Lähdevirta J., Janes R., Kontiainen S., Repo H. Reactive arthritis associated with Shigella sonnei infection. Arthritis Rheum. 1988 Sep;31(9):1190–1193. doi: 10.1002/art.1780310917. [DOI] [PubMed] [Google Scholar]
  25. Mertz A. K., Batsford S. R., Curschellas E., Kist M. J., Gondolf K. B. Cationic Yersinia antigen-induced chronic allergic arthritis in rats. A model for reactive arthritis in humans. J Clin Invest. 1991 Aug;88(2):632–642. doi: 10.1172/JCI115348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Pilz D., Vocke T., Heesemann J., Brade V. Mechanism of YadA-mediated serum resistance of Yersinia enterocolitica serotype O3. Infect Immun. 1992 Jan;60(1):189–195. doi: 10.1128/iai.60.1.189-195.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Schindler R., Gelfand J. A., Dinarello C. A. Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself. Blood. 1990 Oct 15;76(8):1631–1638. [PubMed] [Google Scholar]
  28. Schultz D. R. Induced deficiencies in animals and man. Prog Allergy. 1986;39:101–122. doi: 10.1159/000318540. [DOI] [PubMed] [Google Scholar]
  29. Schwab J. H., Allen J. B., Anderle S. K., Dalldorf F., Eisenberg R., Cromartie W. J. Relationship of complement to experimental arthritis induced in rats with streptococcal cell walls. Immunology. 1982 May;46(1):83–88. [PMC free article] [PubMed] [Google Scholar]
  30. Toivanen A., Merilahti-Palo R., Gripenberg C., Lahesmaa-Rantala R., Söderström K. O., Jaakkola U. M. Yersinia-associated arthritis in the rat: experimental model for human reactive arthritis? Acta Pathol Microbiol Immunol Scand C. 1986 Dec;94(6):261–269. doi: 10.1111/j.1699-0463.1986.tb02121.x. [DOI] [PubMed] [Google Scholar]
  31. VARTIAINEN J., HURRI L. ARTHRITIS DUE TO SALMONELLA TYPHIMURIUM. REPORT OF 12 CASES OF MIGRATORY ARTHRITIS IN ASSOCIATION WITH SALMONELLA TYPHIMURIUM INFECTION. Acta Med Scand. 1964 Jun;175:771–776. [PubMed] [Google Scholar]
  32. Viitanen A. M., Arstila T. P., Lahesmaa R., Granfors K., Skurnik M., Toivanen P. Application of the polymerase chain reaction and immunofluorescence techniques to the detection of bacteria in Yersinia-triggered reactive arthritis. Arthritis Rheum. 1991 Jan;34(1):89–96. doi: 10.1002/art.1780340114. [DOI] [PubMed] [Google Scholar]
  33. Viner N. J., Bailey L. C., Life P. F., Bacon P. A., Gaston J. S. Isolation of Yersinia-specific T cell clones from the synovial membrane and synovial fluid of a patient with reactive arthritis. Arthritis Rheum. 1991 Sep;34(9):1151–1157. doi: 10.1002/art.1780340911. [DOI] [PubMed] [Google Scholar]
  34. de Koning J., Heesemann J., Hoogkamp-Korstanje J. A., Festen J. J., Houtman P. M., van Oijen P. L. Yersinia in intestinal biopsy specimens from patients with seronegative spondyloarthropathy: correlation with specific serum IgA antibodies. J Infect Dis. 1989 Jan;159(1):109–112. doi: 10.1093/infdis/159.1.109. [DOI] [PubMed] [Google Scholar]

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