Miyamoto HD, Ikeda M, Ide T, Tadokoro T, Furusawa S, Abe K, Ishimaru K, Enzan N, Sada M, Yamamoto T, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury
J Am Coll Cardiol Basic Trans Science. 2022;7(8):800-819.
The authors recently became aware that the FerroFarRed (FFR) or Mito-FerroGreen (MFG) used in this study is not an Fe2+ chelator, but instead reduces Fe2+ via conversion to Fe3+ through its reaction. As Fe2+ is critical for lipid peroxidation and ferroptosis and FFR suppresses them in cardiomyocytes under hypoxia/reoxygenation, the overall conclusions are not affected. For clarity, the authors have removed references to FFR- or MFG-mediated chelation throughout. Instead of “chelate”, the wordings of “suppress”, “convert” and “reduce” are used in the corrected paper.
The online version of the paper has been corrected.