Article title: Airway hyperresponsiveness to mannitol in relation to inspiratory and expiratory resistance in subjects with asthma, COPD, and healthy smokers
Authors: Abir Nasr, Georgia Papapostolou, Linnea Jarenbäck, Kerstin Romberg, Alf Tunsäter, Jaro Ankerst, Leif Bjermer and Ellen Tufvesson
Journal: European Clinical Respiratory Journal
Bibliometrics: Volume 12, Number 01, pages 1-12
DOI: https://doi.org/10.1080/20018525.2025.2546677
It has been noted by the authors that Tables 1 and 2 were not included in the originally published article. The correct Tables 1 and 2 are provided below, and the original article has been updated to include them.
Table 1.
Subject characteristics.
| Asthma | Healthynever-smokers | COPD | Healthy smoker | ||||
|---|---|---|---|---|---|---|---|
| |
n=239 |
n=15 |
p-valuee |
n=25 |
n=14 |
p-valuef |
p-valueg |
| Age, years | 49(34–58) | 47(34–66) | 0.62 | 69(66–74) | 60(58–67) | 0.0043 | <0.0001 |
| Sex, females/males,n (%) | 127/112 (53/47) |
8/7(53/47) | 0.98 | 20/5 (80/20) |
8/6(57/43) | 0.13 | 0.01 |
| Height, m | 1.73(1.67–1.80) | 1.74(1.69–1.81) | 0.86 | 1.65(1.61–1.72) | 1.70(1.67–1.79) | 0.021 | 0.0002 |
| BMI, kg/m2 | 25 (23–28) | 23 (22–25) | 0.12 | 26 (24–29) | 26(22–31) | 0.57 | 0.18 |
| FeNOa, ppb | 19 (12-31) | 20 (15-24) | 0.86 | 13(9-18) | 8 (6–12) | 0.04 | 0.0027 |
| Atopyb, n (%) | 148 (62) | n.d. | n.a. | 1 (4) | 0 | >0.99 | <0.0001 |
| Eosinophilc | 0.2 (0.10–0.3) | 0.1(0.1-0.15) | 0.019 | 0.2 (0.2–0.4) | 0.1(0.1–0.2) | 0.0088 | 0.24 |
| Non-smoker/ex-smokerd/smoker, n | 157/8/74 | 15/0/0 | 0.021 | 1/17/7 | 0/2/12 | 0.001 | <0.001 |
| Packyears | 0(0–1) | n. a. | n.a | 26(13–39) | 38(30–48) | 0.061 | <0.0001 |
Data is presented as median (IQR) if not otherwise stated.
aFeNO was missing in 10 subjects (5 asthma, 1 healthy never-smoker, 3 COPD and 1 healthy smoker).bOne missing phadiatop test (atopy) in COPD.cEosinophil test was not performed in 8 subjects (1 asthma and 7 healthy never-smokers).dEx-smokers were defined as former smokers with ≥ 5 pack-years of smoking history.
eComparison between asthma and healthy never-smokers.fComparison between COPD and healthy smokers. gComparison between asthma and COPD.
n. a.=non-applicable, BMI=body mass index, FeNO=fractional exhaled NO.
Table 2.
Correlations between the relative change in % from baseline to last dose in FEV1 (=Δ%FEV1) and in respiratory oscillometry indices (Δ%R5, Δ%R19 and Δ%X5) among subjects with negative and positive mannitol test.
| Δ%R5insp | Δ%R5exp | Δ%R19insp | Δ%R19exp | Δ%X5insp | Δ%X5exp | ||
|---|---|---|---|---|---|---|---|
| Asthma | |||||||
| Neg. mannitol test | r | 0.049 | 0.12 | 0.031 | 0.020 | 0.019 | 0.11 |
| p | 0.54 | 0.13 | 0.70 | 0.80 | 0.82 | 0.18 | |
| Pos. mannitol test | r | 0.013 | -0.016 | 0.10 | -0.044 | -0.12 | -0.044 |
| p | 0.91 | 0.89 | 0.35 | 0.69 | 0.28 | 0.69 | |
| COPD | |||||||
| Neg. mannitol test | r | 0.35 | 0.23 | 0.22 | -0.28 | 0.67 | 0.27 |
| p | 0.27 | 0.47 | 0.50 | 0.38 | 0.02 | 0.39 | |
| Pos. mannitol test | r | 0.028 | 0.46 | 0.17 | 0.24 | 0.38 | 0.44 |
| p | 0.93 | 0.11 | 0.57 | 0.42 | 0.19 | 0.13 | |
| Healthy Smokers | |||||||
| Neg. mannitol test | r | 0.57 | 0.11 | -0.14 | -0.25 | 0.32 | -0.50 |
| p | 0.20 | 0.84 | 0.78 | 0.59 | 0.50 | 0.27 | |
| Pos. mannitol test | r | -0.36 | -0.82 | -0.75 | -0.82 | -0.64 | -0.32 |
| p | 0.44 | 0.034 | 0.066 | 0.034 | 0.14 | 0.50 |
r=Spearman´s rank correlation coefficient.
This correction does not affect the description, interpretation, or conclusions of the article.
