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. 1972 Jul;224(1):173–186. doi: 10.1113/jphysiol.1972.sp009887

Reflex cardiovascular and respiratory responses originating in exercising muscle

D I McCloskey, J H Mitchell
PMCID: PMC1331532  PMID: 5039977

Abstract

1. In anaesthetized and decerebrate cats isometric exercise of the hind limb muscles was elicited by stimulating the spinal ventral roots L7-S1. This caused a rise in arterial blood pressure, with small increases in heart rate and pulmonary ventilation. These changes were abolished by cutting the dorsal roots receiving afferents from the exercising muscle.

2. When the triceps surae muscle was made to exercise by ventral root stimulation, occlusion of the femoral artery and vein through and beyond the period of exercise caused the blood pressure to remain raised until the occlusion was removed. The ventilatory and heart rate responses were not markedly altered or prolonged by such circulatory occlusion.

3. Injection of small volumes of 5% NaCl or isotonic KCl into the arterial blood supplying hind limb muscles gave cardiovascular and respiratory responses similar to those evoked by exercise. Like the responses to exercise, these responses were abolished by dorsal root section.

4. Direct current anodal block of the dorsal roots receiving afferents from the exercising muscle was used to block preferentially large myelinated fibres: this form of block did not abolish the evoked cardiovascular and respiratory responses. Local anaesthetic block of the dorsal roots was used to block preferentially unmyelinated and small myelinated fibres: this form of block abolished the cardiovascular and respiratory responses. It is concluded that the reflex responses are mediated by fibres within groups III and IV (small myelinated fibres and unmyelinated fibres).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alam M., Smirk F. H. Observations in man on a pulse-accelerating reflex from the voluntary muscles of the legs. J Physiol. 1938 Mar 14;92(2):167–177. doi: 10.1113/jphysiol.1938.sp003592. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Alam M., Smirk F. H. Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol. 1937 Jun 3;89(4):372–383. doi: 10.1113/jphysiol.1937.sp003485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Biscoe T. J., Purves M. J. Factors affecting the cat carotid chemoreceptor and cervical sympathetic activity with special reference to passive hind-limb movements. J Physiol. 1967 Jun;190(3):425–441. doi: 10.1113/jphysiol.1967.sp008219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown M. C., Lawrence D. G., Matthews P. B. Static fusimotor fibres and the position sensitivity of muscle spindle receptors. Brain Res. 1969 Jun;14(1):173–187. doi: 10.1016/0006-8993(69)90038-9. [DOI] [PubMed] [Google Scholar]
  5. Casey K. L., Blick M. Observations on anodal polarization of cutaneous nerve. Brain Res. 1969 Mar;13(1):155–167. doi: 10.1016/0006-8993(69)90150-4. [DOI] [PubMed] [Google Scholar]
  6. Coote J. H., Hilton S. M., Perez-Gonzalez J. F. The reflex nature of the pressor response to muscular exercise. J Physiol. 1971 Jul;215(3):789–804. doi: 10.1113/jphysiol.1971.sp009498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Coote J. H., Perez-Gonzalez J. F. The response of some sympathetic neurones to volleys in various afferent nerves. J Physiol. 1970 Jun;208(2):261–278. doi: 10.1113/jphysiol.1970.sp009118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gordon G. The mechanism of the vasomotor reflexes produced by stimulating mammalian sensory nerves. J Physiol. 1943 Jun 30;102(1):95–107. doi: 10.1113/jphysiol.1943.sp004019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. HARVEY R. J., MATTHEWS P. B. Some effects of stimulation of the muscle nerve on afferent endings of muscle spindles, and the classification of their responses into types A1 and A2. J Physiol. 1961 May;156:470–497. doi: 10.1113/jphysiol.1961.sp006688. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hník P., Hudlická O., Kucera J., Payne R. Activatioof muscle afferents by nonproprioceptive stimuli. Am J Physiol. 1969 Nov;217(5):1451–1457. doi: 10.1152/ajplegacy.1969.217.5.1451. [DOI] [PubMed] [Google Scholar]
  11. KAO F. F., RAY L. H. Respiratory and circulatory responses of anesthetized dogs to induced muscular work. Am J Physiol. 1954 Nov;179(2):249–254. doi: 10.1152/ajplegacy.1954.179.2.249. [DOI] [PubMed] [Google Scholar]
  12. Krogh A., Lindhard J. The regulation of respiration and circulation during the initial stages of muscular work. J Physiol. 1913 Oct 17;47(1-2):112–136. doi: 10.1113/jphysiol.1913.sp001616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. LEE K. D., MAYOU R. A., TORRANCE R. W. THE EFFECT OF BLOOD PRESSURE UPON CHEMORECEPTOR DISCHARGE TO HYPOXIA, AND THE MODIFICATION OF THIS EFFECT BY THE SYMPATHETIC-ADRENAL SYSTEM. Q J Exp Physiol Cogn Med Sci. 1964 Apr;49:171–183. doi: 10.1113/expphysiol.1964.sp001717. [DOI] [PubMed] [Google Scholar]
  14. Leitner L. M., Dejours P. Reflex increase in ventilation induced by vibrations applied to the triceps surae muscles in the cat. Respir Physiol. 1971 Jun;12(2):199–204. doi: 10.1016/0034-5687(71)90052-1. [DOI] [PubMed] [Google Scholar]
  15. MENDELL L. M., WALL P. D. PRESYNAPTIC HYPERPOLARIZATION: A ROLE FOR FINE AFFERENT FIBRES. J Physiol. 1964 Aug;172:274–294. doi: 10.1113/jphysiol.1964.sp007417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mitchell J. H., Mierzwiak D. S., Wildenthal K., Willis W. D., Jr, Smith A. M. Effect on left ventricular performance of stimulation of an afferent nerve from muscle. Circ Res. 1968 Apr;22(4):507–516. doi: 10.1161/01.res.22.4.507. [DOI] [PubMed] [Google Scholar]
  17. Myhre K., Andersen K. L. Respiratory responses to static muscular work. Respir Physiol. 1971 Apr;12(1):77–89. doi: 10.1016/0034-5687(71)90103-4. [DOI] [PubMed] [Google Scholar]
  18. Parida B., Senapati J. M., Kalia M. Role of carotid body in hyperpnea due to stimulation of muscle receptors in the dog. J Appl Physiol. 1969 Oct;27(4):519–522. doi: 10.1152/jappl.1969.27.4.519. [DOI] [PubMed] [Google Scholar]
  19. Senapati J. M. Effect of stimulation of muscle afferents on ventilation of dogs. J Appl Physiol. 1966 Jan;21(1):242–246. doi: 10.1152/jappl.1966.21.1.242. [DOI] [PubMed] [Google Scholar]
  20. Wildenthal K., Mierzwiak D. S., Skinner N. S., Jr, Mitchell J. H. Potassium-induced cardiovascular and ventilatory reflexes from the dog hindlimb. Am J Physiol. 1968 Sep;215(3):542–548. doi: 10.1152/ajplegacy.1968.215.3.542. [DOI] [PubMed] [Google Scholar]
  21. Wiley R. L., Lind A. R. Respiratory responses to sustained static muscular contractions in humans. Clin Sci. 1971 Mar;40(3):221–234. doi: 10.1042/cs0400221. [DOI] [PubMed] [Google Scholar]

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