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. 1975 Apr;181(4):412–417. doi: 10.1097/00000658-197504000-00008

Twenty-four hour left ventricular bypass with a centrifugal blood pump.

E F Berstein, G A DeLaria, K H Johansen, R L Shuman, P Stasz, S Reich
PMCID: PMC1343780  PMID: 1130859

Abstract

A new centrifugal blood pump system has been developed for left ventricular bypass by the addition of non-thrombogenic blood surface materials and an ultrathin-walled cannula for the retrograde cannulation of the left ventricle. Partial LV bypass at 3 to 6 L/min was undertaken in 55 calves without thoracotomy. In 20 it was continued for 24 hours, with 13 survivors who were eventually sacrificed. Eleven of the last 14 experiments were completed without mishap. Heparin was employed only during pump insertion. Hematologic changes were limited to moderate platelet depression, and tolerable hemolysis (average serum level 21 mg% in the last 13 experiments). Normal clotting parameters and the absence of significant fibrin split product formation correlated with the absence of gross thrombosis and few minor renal emboli observed at autopsy. This pump system appears to have several advantages over previously described equipment for LV bypass.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berger R. L., Saini V. K., Ryan T. J., Sokol D. M., Keefe J. F. Intra-aortic balloon assist for postcardiotomy cardiogenic shock. J Thorac Cardiovasc Surg. 1973 Dec;66(6):906–915. [PubMed] [Google Scholar]
  2. Bernhard W. F., LaFarge C. G., Husain M., Yamamura N., Robinson T. C. Physiologic observations during partial and total left heart bypass. J Thorac Cardiovasc Surg. 1970 Dec;60(6):807–817. [PubMed] [Google Scholar]
  3. Bernstein E. F., Dorman F. D., Blackshear P. L., Jr, Scott D. R. An efficient, compact blood pump for assisted circulation. Surgery. 1970 Jul;68(1):105–115. [PubMed] [Google Scholar]
  4. CONNOLLY J. E., BACANER M. B., BRUNS D. L., LOWENSTEIN J. M., STORLI E. Mechanical support of the circulation in acute heart failure. Surgery. 1958 Jul;44(1):255–262. [PubMed] [Google Scholar]
  5. DENNIS C., HALL D. P., MORENO J. R., SENNING A. Reduction of the oxygen utilization of the heart by left heart bypass. Circ Res. 1962 Mar;10:298–305. doi: 10.1161/01.res.10.3.298. [DOI] [PubMed] [Google Scholar]
  6. DeLaria G. A., Johansen K. H., Levine I. D., Bernstein E. F. Reduction in myocardial ischemia by left ventricular bypass after acute coronary artery occlusion. J Thorac Cardiovasc Surg. 1974 May;67(5):826–837. [PubMed] [Google Scholar]
  7. Dorman F., Bernstein E. F., Blackshear P. L., Sovilj R., Scott D. R. Progress in the design of a centrifugal cardiac assist pump with trans-cutaneous energy transmission by magnetic coupling. Trans Am Soc Artif Intern Organs. 1969;15:441–448. [PubMed] [Google Scholar]
  8. Dunkman W. B., Leinbach R. C., Buckley M. J., Mundth E. D., Kantrowitz A. R., Austen W. G., Sanders C. A. Clinical and hemodynamic results of intraaortic balloon pumping and surgery for cardiogenic shock. Circulation. 1972 Sep;46(3):465–477. doi: 10.1161/01.cir.46.3.465. [DOI] [PubMed] [Google Scholar]
  9. Duvelleroy M. A., Buckles R. G., Rosenkaimer S., Tung C., Laver M. B. An oxyhemoglobin dissociation analyzer. J Appl Physiol. 1970 Feb;28(2):227–233. doi: 10.1152/jappl.1970.28.2.227. [DOI] [PubMed] [Google Scholar]
  10. HALL D. P., MORENO J. R., DENNIS C., SENNING A. An experimental study of prolonged left heart bypass without thoracotomy. Ann Surg. 1962 Aug;156:190–196. doi: 10.1097/00000658-196208000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Harker L. A., Finch C. A. Thrombokinetics in man. J Clin Invest. 1969 Jun;48(6):963–974. doi: 10.1172/JCI106077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LANGDELL R. D., WAGNER R. H., BRINKHOUS K. M. Effect of antihemophilic factor on one-stage clotting tests; a presumptive test for hemophilia and a simple one-stage antihemophilic factor assy procedure. J Lab Clin Med. 1953 Apr;41(4):637–647. [PubMed] [Google Scholar]
  13. Merskey C., Lalezari P., Johnson A. J. A rapid, simple, sensitive method for measuring fibrinolytic split products in human serum. Proc Soc Exp Biol Med. 1969 Jul;131(3):871–875. doi: 10.3181/00379727-131-33998. [DOI] [PubMed] [Google Scholar]
  14. Pierce W. S., Aaronson A. E., Prophet G. A., Williams D. R., Waldhausen J. A. Hemodynamic and metabolic studies during two types of left ventricular bypass. Surg Forum. 1972;23(0):176–178. [PubMed] [Google Scholar]
  15. Pierce W. S., Brighton J. A., O'Bannon W., Phillips W. M., Landis D. L., White W. J., Prophet G. A., Waldhausen J. A. Prolonged left ventricle-to-aorta pumping with left ventricular decompression using a paracorporeal pump: experimental study in the calf. Surg Forum. 1973;24:156–158. [PubMed] [Google Scholar]
  16. Scheidt S., Wilner G., Mueller H., Summers D., Lesch M., Wolff G., Krakauer J., Rubenfire M., Fleming P., Noon G. Intra-aortic balloon counterpulsation in cardiogenic shock. Report of a co-operative clinical trial. N Engl J Med. 1973 May 10;288(19):979–984. doi: 10.1056/NEJM197305102881901. [DOI] [PubMed] [Google Scholar]
  17. Weber K. T., Janicki J. S. Intraaortic balloon counterpulsation. A review of physiological principles, clinical results, and device safety. Ann Thorac Surg. 1974 Jun;17(6):602–636. doi: 10.1016/s0003-4975(10)65706-2. [DOI] [PubMed] [Google Scholar]
  18. Zwart H. H., Kralios A., Backman D. K., Eastwood N., Kolff W. J. The effects of transarterial left ventricular bypass on hemodynamics of the failing left ventricle in sheep. Ann Surg. 1973 Dec;178(6):710–714. doi: 10.1097/00000658-197312000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Zwart H. H., Kralios A., Collan R., Kolff W. J. Transarterial closed-chest left ventricular (TaCLV) bypass. Trans Am Soc Artif Intern Organs. 1969;15:386–390. [PubMed] [Google Scholar]

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