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. 1977 Dec;273(1):45–55. doi: 10.1113/jphysiol.1977.sp012080

Further evidence for adrenergic transmission in the human vas deferens.

P G Anton, J C McGrath
PMCID: PMC1353725  PMID: 23430

Abstract

1. Isolated portions of human vas deferens responded to field stimulation of the intramural nerve fibres or to exogenously applied noradrenaline with rhythmical contractions of both longitudinal and circular muscle layers. 2. In guinea-pig and rabbit vas deferens field stimulation produced an initial rapid 'twitch' response which was not found with human vasa. 3. Responses of the human vas to field stimulation were depressed by the alpha-adrenoceptor blocking agents phentolamine and yohimbine. 4. It is concluded that the motor innervation of the human vas deferens is adrenergic and the relevance of this to the physiological operation of the tissue is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ambache N., Zar M. A. Evidence against adrenergic motor transmission in the guinea-pig vas deferens. J Physiol. 1971 Jul;216(2):359–389. doi: 10.1113/jphysiol.1971.sp009530. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anstey M. D., Birmingham A. T., Tomlinson D. R. Proceedings: The noradrenaline concentration and the cholinesterase activity of the separated longitudinal and circular layers of muscle of the guinea-pig vas deferens. Br J Pharmacol. 1974 Mar;50(3):454P–455P. [PMC free article] [PubMed] [Google Scholar]
  3. Anton P. G., Duncan M. E., McGrath J. C. An analysis of the anatomical basis for the mechanical response to motor nerve stimulation of the rat vas deferens. J Physiol. 1977 Dec;273(1):23–43. doi: 10.1113/jphysiol.1977.sp012079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Birmingham A. T. The human isolated vas deferens: its response to electrical stimulation and to drugs. Br J Pharmacol. 1968 Nov;34(3):692P–693P. [PMC free article] [PubMed] [Google Scholar]
  5. Drew G. M. Effects of alpha-adrenoceptor agonists and antagonists on pre- and postsynaptically located alpha-adrenoceptors. Eur J Pharmacol. 1976 Apr;36(2):313–320. doi: 10.1016/0014-2999(76)90084-4. [DOI] [PubMed] [Google Scholar]
  6. Duncan M. E., McGrath J. C. Proceedings: Observations on the origin of the complex mechanical response to motor nerve stimulation of the rat vas deferens. J Physiol. 1976 Jul;259(1):54P–55P. [PubMed] [Google Scholar]
  7. Freund M., Davis J. E. Disappearance rate of spermatozoa from the ejaculate following vasectomy. Fertil Steril. 1969 Jan-Feb;20(1):163–170. doi: 10.1016/s0015-0282(16)36914-x. [DOI] [PubMed] [Google Scholar]
  8. Furness J. B., Iwayama T. The arrangement and identification of axons innervating the vas deferens of the guinea-pig. J Anat. 1972 Nov;113(Pt 2):179–196. [PMC free article] [PubMed] [Google Scholar]
  9. Gosling J. A., Dixon J. S. Differences in the manner of autonomic innervation of the muscle layers of the guinea-pig ductus deferens. J Anat. 1972 May;112(Pt 1):81–91. [PMC free article] [PubMed] [Google Scholar]
  10. Hedqvist P., Von Euler U. S. Inhibition by alpha- and beta-adrenoceptors of the twitch response to transmural stimulation in the guinea-pig vas deferens. Eur J Pharmacol. 1976 Nov;40(1):153–162. doi: 10.1016/0014-2999(76)90365-4. [DOI] [PubMed] [Google Scholar]
  11. Jenkins D. A., Marshall I., Nasmyth P. A. Proceedings: Is noradrenaline the motor transmitter in the mouse vas deferens? J Physiol. 1976 Jan;254(1):49P–50P. [PMC free article] [PubMed] [Google Scholar]
  12. Langer S. Z., Adler-Graschinsky E., Giorgi O. Physiological significance of alpha-adrenoceptor-mediated negative feedback mechanism regulating noradrenaline release during nerve stimulation. Nature. 1977 Feb 17;265(5595):648–650. doi: 10.1038/265648a0. [DOI] [PubMed] [Google Scholar]
  13. Marshall I., Nasmyth P. A., Nicholl C. G., Shepperson N. B. Pre-synaptic alpha-adrenoceptor regulation of the twitch response of the mouse vas deferens [proceedings]. Br J Pharmacol. 1977 Mar;59(3):510P–510P. [PMC free article] [PubMed] [Google Scholar]
  14. Starke K., Borowski E., Endo T. Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine. Eur J Pharmacol. 1975 Dec;34(2):385–388. doi: 10.1016/0014-2999(75)90268-x. [DOI] [PubMed] [Google Scholar]

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