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. 1979 Jan;189(1):120–128. doi: 10.1097/00000658-197901000-00023

Abnormalities of zinc and copper during total parenteral nutrition.

S F Lowry, J T Goodgame Jr, J C Smith, M M Maher, R W Makuch, R I Henkin, M F Brennan
PMCID: PMC1396940  PMID: 103506

Abstract

Changes in serum zinc and copper levels were studied in 19 tumor bearing patients undergoing parenteral nutrition (TPN) for five to 42 days. Before initiation of intravenous feeding mean serum zinc and copper concentrations were within normal limits but during TPN levels decreased significantly below those measured prior to parenteral nutrition. During TPN nitrogen, zinc, and copper intake, urinary output and serum levels were studied prospectively in nine of these patients. These nine patients exhibited positive nitrogen retention based upon urinary nitrogen excretion, but elevated urinary zinc and copper excretion and lowered serum zinc and copper concentrations. Neither blood administration nor limited oral intake was consistently able to maintain normal serum levels of zinc or copper. Zinc and copper supplementation of hyperalimentation fluids in four patients studied for five to 16 days was successful in increasing serum zinc and copper levels in only two. The data obtained suggest that patients undergoing parenteral nutrition may require supplementation of zinc and copper to prevent deficiencies of these elements.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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