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. 1977 Oct;18(10):805–813. doi: 10.1136/gut.18.10.805

Effects of long chain fatty acids on solute absorption: perfusion studies in the human jejunum.

H V Ammon, P J Thomas, S F Phillips
PMCID: PMC1411680  PMID: 590838

Abstract

Perfusion studies were performed in healthy volunteers to test the hypothesis that net fluid secretion induced by fatty acids is accompanied by parallel reduction in solute transport. Ricinoleic acid provoked a marked net secretion of fluid and concomitantly inhibited the absorption of all solutes tested; these included glucose, xylose, L-leucine, L-lysine, Folic acid, and 2-mono-olein. Oleic acid also reduced net fluid and solute transport, but was less potent in reducing solute absorption than was ricinoleic acid. When fluid secretion was induced osmotically with mannitol, glucose and xylose absorption was not affected. The mechanism for this generalised effect of fatty acids on solute absorption is uncertain, possibly nonspecific, and might be related to mucosal damage and altered mucosal permeability induced by these agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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