Abstract
Some recent discoveries about the formation, storage and catabolism of histamine are reviewed. Histamine is formed by decarboxylation of histidine and stored principally in the mast cells of connective tissue. Human lung and facial skin are particularly rich in histamine. When histamine is injected intravenously, simulating spontaneous release, it is rapidly metabolized and excreted.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BEALL G. N., VANARSDEL P. P., Jr Histamine metabolism in human disease. J Clin Invest. 1960 Apr;39:676–683. doi: 10.1172/JCI104083. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BROWN D. D., SILVA O. L., McDONALD P. B., SNYDER S. H., KIES M. W. The mammalian metabolism of L-histidine. III. The urinary metabolites of L-histidine-C14 in the monkey, human, and rat. J Biol Chem. 1960 Jan;235:154–159. [PubMed] [Google Scholar]
- COOPER J. A., SCHAYER R. W. Metabolism of C14 histamine in man. J Appl Physiol. 1956 Nov;9(3):481–483. doi: 10.1152/jappl.1956.9.3.481. [DOI] [PubMed] [Google Scholar]
- GRAHAM H. T., LOWRY O. H., WAHL N., PRIEBAT M. K. Mast cells as sources of tissue histamine. J Exp Med. 1955 Sep 1;102(3):307–318. doi: 10.1084/jem.102.3.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GRAHAM H. T., LOWRY O. H., WHEELWRIGHT F., LENZ M. A., PARISH H. H., Jr Distribution of histamine among leukocytes and platelets. Blood. 1955 May;10(5):467–481. [PubMed] [Google Scholar]
- SCHAYER R. W. Biogenesis of histamine. J Biol Chem. 1952 Nov;199(1):245–250. [PubMed] [Google Scholar]
- SCHAYER R. W. Catabolism of physiological quantities of histamine in vivo. Physiol Rev. 1959 Jan;39(1):116–126. doi: 10.1152/physrev.1959.39.1.116. [DOI] [PubMed] [Google Scholar]
- VALENTINE W. N., LAWRENCE J. S., PEARCE M. L., BECK W. S. The relationship of the basophil to blood histamine in man. Blood. 1955 Feb;10(2):154–159. [PubMed] [Google Scholar]