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. 1981 Apr;56(4):258–263. doi: 10.1136/adc.56.4.258

Hypertrophic cardiomyopathy in infants of poorly-controlled diabetic mothers.

H L Halliday
PMCID: PMC1627227  PMID: 7195689

Abstract

Twelve newborn infants of poorly-controlled diabetic mothers were transferred from outlying maternity hospitals for neonatal intensive care. Respiratory distress and cardiomegaly were the presenting signs. Ten infants were large for dates (macrosomic) and had echocardiographic evidence of myocardial hypertrophy, reduced ejection time, and systolic anterior movement of the mitral valve (in 6 infants). These findings are similar to those of adults with idiopathic hypertrophic subaortic stenosis. Two infants died. In survivors the myocardial hypertrophy persisted for at least 2 weeks but the evidence of functional subaortic stenosis had disappeared by 4-7 days. The 2 infants who were appropriately grown had cardiomegaly as a result of ventricular dilatation. This was associated with hypoglycaemia and acidosis, and disappeared when these metabolic disturbances were corrected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbasi A. S., MacAlpin R. N., Eber L. M., Pearce M. L. Echocardiographic diagnosis of idiopathic hypertrophic cardiomyopathy without outflow obstruction. Circulation. 1972 Nov;46(5):897–904. doi: 10.1161/01.cir.46.5.897. [DOI] [PubMed] [Google Scholar]
  2. Amatayakul O., Cumming G. R., Haworth J. C. Association of hypoglycaemia with cardiac enlargement and heart failure in newborn infants. Arch Dis Child. 1970 Oct;45(243):717–720. doi: 10.1136/adc.45.243.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barr P. A., Celermajer J. M., Bowdler J. D., Cartmill T. B. Idiopathic hypertrophic obstructive cardiomyopathy causing severe right ventricular outflow tract obstruction in infancy. Br Heart J. 1973 Nov;35(11):1109–1115. doi: 10.1136/hrt.35.11.1109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Boughner D. R., Schuld R. L., Persaud J. A. Hypertrophic obstructive cardiomyopathy. Assessment by echocardiographic and Doppler ultrasound techniques. Br Heart J. 1975 Sep;37(9):917–923. doi: 10.1136/hrt.37.9.917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gutgesell H. P., Mullins C. E., Gillette P. C., Speer M., Rudolph A. J., McNamara D. G. Transient hypertrophic subaortic stenosis in infants of diabetic mothers. J Pediatr. 1976 Jul;89(1):120–125. doi: 10.1016/s0022-3476(76)80945-6. [DOI] [PubMed] [Google Scholar]
  6. Hagan A. D., Deely W. J., Sahn D., Friedman W. F. Echocardiographic criteria for normal newborn infants. Circulation. 1973 Dec;48(6):1221–1226. doi: 10.1161/01.cir.48.6.1221. [DOI] [PubMed] [Google Scholar]
  7. Halliday H., Hirschfeld S., Riggs T., Liebman J., Fanaroff A. Echographic ventricular systolic time intervals in normal term and preterm neonates. Pediatrics. 1978 Sep;62(3):317–321. [PubMed] [Google Scholar]
  8. Henry W. L., Clark C. E., Epstein S. E. Asymmetric septal hypertrophy. Echocardiographic identification of the pathognomonic anatomic abnormality of IHSS. Circulation. 1973 Feb;47(2):225–233. doi: 10.1161/01.cir.47.2.225. [DOI] [PubMed] [Google Scholar]
  9. Hirschfeld S., Meyer R., Schwartz D. C., Korfhagen J., Kaplan S. Measurement of right and left ventricular systolic time intervals by echocardiography. Circulation. 1975 Feb;51(2):304–309. doi: 10.1161/01.cir.51.2.304. [DOI] [PubMed] [Google Scholar]
  10. Lewis R. P., Sandler H. Relationship between changes in left ventricular dimensions and the ejection fraction in man. Circulation. 1971 Oct;44(4):548–557. doi: 10.1161/01.cir.44.4.548. [DOI] [PubMed] [Google Scholar]
  11. Maron B. J., Edwards J. E., Henry W. L., Clark C. E., Bingle G. J., Epstein S. E. Asymmetric septal hypertrophy (ASH) in infancy. Circulation. 1974 Oct;50(4):809–820. doi: 10.1161/01.cir.50.4.809. [DOI] [PubMed] [Google Scholar]
  12. NAEYE R. L. INFANTS OF DIABETIC MOTHERS: A QUANTITATIVE, MORPHOLOGIC STUDY. Pediatrics. 1965 Jun;35:980–988. [PubMed] [Google Scholar]
  13. Reid M. M., Reilly B. J., Murdock A. I., Swyer P. R. Cardiomegaly in association with neonatal hypoglycaemia. Acta Paediatr Scand. 1971 May;60(3):295–298. doi: 10.1111/j.1651-2227.1971.tb06659.x. [DOI] [PubMed] [Google Scholar]
  14. SCHULZ D. M., GIORDANO D. A., SCHULZ D. H. Weights of organs of fetuses and infants. Arch Pathol. 1962 Sep;74:244–250. [PubMed] [Google Scholar]
  15. Shah P. M., Gramiak R., Adelman A. G., Wigle E. D. Role of echocardiography in diagnostic and hemodynamic assessment of hypertrophic subaortic stenosis. Circulation. 1971 Nov;44(5):891–898. doi: 10.1161/01.cir.44.5.891. [DOI] [PubMed] [Google Scholar]
  16. Shand D. G., Sell C. G., Oates J. A. Hypertrophic obstructive cardiomyopathy in an infant--propranolol therapy for three years. N Engl J Med. 1971 Oct 7;285(15):843–844. doi: 10.1056/NEJM197110072851507. [DOI] [PubMed] [Google Scholar]
  17. Solinger R., Elbl F., Minhas K. Echocardiography in the normal neonate. Circulation. 1973 Jan;47(1):108–118. doi: 10.1161/01.cir.47.1.108. [DOI] [PubMed] [Google Scholar]
  18. Thomson A. M., Billewicz W. Z., Hytten F. E. The assessment of fetal growth. J Obstet Gynaecol Br Commonw. 1968 Sep;75(9):903–916. doi: 10.1111/j.1471-0528.1968.tb01615.x. [DOI] [PubMed] [Google Scholar]
  19. WHITE P. PREGNANCY AND DIABETES, MEDICAL ASPECTS. Med Clin North Am. 1965 Jul;49:1015–1024. doi: 10.1016/s0025-7125(16)33292-8. [DOI] [PubMed] [Google Scholar]

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