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. 1932 Jul 31;56(2):267–289. doi: 10.1084/jem.56.2.267

THE PRODUCTION OF OSTEOGENIC SARCOMATA AND THE EFFECTS ON LYMPH NODES AND BONE MARROW OF INTRAVENOUS INJECTIONS OF RADIUM CHLORIDE AND MESOTHORIUM IN RABBITS

F R Sabin 1, C A Doan 1, C E Forkner 1
PMCID: PMC2132174  PMID: 19870065

Abstract

The observations in this work suggest that with certain doses of radioactive material, the fundamental damage in the lymphoid tissues is to the stem cell and that the damage is to the chromatin of the nuclei of these cells. The erythroid tissues are apparently less susceptible to radioactive material than the lymphoid tissues but an original anemia of secondary type from peripheral destruction may eventually be changed to one of primary type through decreased maturation of primitive cells in the marrow. The damage of lymph nodes and bone marrow leads to atrophy of these organs. The cells of the liver and thymus suffer nuclear damage of the same general character as is seen in the lymph nodes, and there is an atrophy of these organs. The storage of the radioactive material in the bones gave rise to osteogenic sarcomata in two out of seven rabbits surviving from 11 to 19 months. A repetition of the experiment has been undertaken with more intensive studies to test the validity of the findings.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Drury D. R. TOTAL SURGICAL REMOVAL OF THE LIVER IN RABBITS. J Exp Med. 1929 Apr 30;49(5):759–764. doi: 10.1084/jem.49.5.759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Hussey R. G. GENERAL LEUCOCYTIC RESPONSE OF THE GUINEA PIG DURING THE REACTION OF ARTIFICIAL IMMUNITY IN EXPERIMENTAL TUBERCULOUS INFECTION. J Exp Med. 1921 Feb 28;33(3):337–348. doi: 10.1084/jem.33.3.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. McMaster P. D., Drury D. R. THE PRODUCTION OF PARTIAL LIVER INSUFFICIENCY IN RABBITS. J Exp Med. 1929 Apr 30;49(5):745–758. doi: 10.1084/jem.49.5.745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Mottram J. C. Some Effects of Exposure to Radium on the Blood Platelets. Proc R Soc Med. 1923;16(PATHOL):9–13. doi: 10.1177/003591572301601302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Murphy J. B., Ellis A. W. EXPERIMENTS ON THE ROLE OF LYMPHOID TISSUE IN THE RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN MICE. J Exp Med. 1914 Oct 1;20(4):397–403. doi: 10.1084/jem.20.4.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Murphy J. B., Liu J. H., Sturm E. STUDIES ON X-RAY EFFECTS : IX. THE ACTION OF SERUM FROM X-RAYED ANIMALS ON LYMPHOID CELLS IN VITRO. J Exp Med. 1922 Feb 28;35(3):373–384. doi: 10.1084/jem.35.3.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Murphy J. B., Morton J. J. The Lymphocyte as a Factor in Natural and Induced Resistance to Transplanted Cancer. Proc Natl Acad Sci U S A. 1915 Jul;1(7):435–437. doi: 10.1073/pnas.1.7.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Murphy J. B., Sturm E. A COMPARISON OF THE EFFECTS OF X-RAY AND DRY HEAT ON ANTIBODY FORMATION. J Exp Med. 1925 Jan 31;41(2):245–255. doi: 10.1084/jem.41.2.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nakahara W., Murphy J. B. STUDIES ON X-RAY EFFECTS : V. EFFECT OF SMALL DOSES OF X-RAYS OF LOW PENETRATION ON THE LYMPHOID TISSUE OF MICE. J Exp Med. 1920 Jan 1;31(1):13–29. doi: 10.1084/jem.31.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nakahara W., Murphy J. B. THE LYMPHOCYTE IN NATURAL AND INDUCED RESISTANCE TO TRANSPLANTED CANCER : VI. HISTOLOGICAL COMPARISON OF THE LYMPHOID TISSUE OF NATURALLY IMMUNE AND SUSCEPTIBLE MICE. J Exp Med. 1921 Feb 28;33(3):327–336. doi: 10.1084/jem.33.3.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nakahara W. STUDIES ON X-RAY EFFECTS : III. CHANGES IN THE LYMPHOID ORGANS AFTER SMALL DOSES OF X-RAYS. J Exp Med. 1919 Jan 1;29(1):83–87. doi: 10.1084/jem.29.1.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sabin F. R., Austrian C. R., Cunningham R. S., Doan C. A. STUDIES ON THE MATURATION OF MYELOBLASTS INTO MYELOCYTES AND ON AMITOTIC CELL DIVISION IN THE PERIPHERAL BLOOD IN SUBACUTE MYELOBLASTIC LEUCEMIA. J Exp Med. 1924 Nov 30;40(6):845–871. doi: 10.1084/jem.40.6.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Taylor H. D., Murphy J. B. EXPERIMENTS ON THE ROLE OF LYMPHOID TISSUE IN THE RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN MICE : II. EFFECT OF CANCER IMMUNITY ON RESISTANCE TO TUBERCULOSIS. J Exp Med. 1917 May 1;25(5):609–617. doi: 10.1084/jem.25.5.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Thomas M. M., Taylor H. D., Witherbee W. D. STUDIES ON X-RAY EFFECTS : II. STIMULATIVE ACTION ON THE LYMPHOCYTES. J Exp Med. 1919 Jan 1;29(1):75–82. doi: 10.1084/jem.29.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Thomas R. M. THE DIPHASIC NATURE OF TUBERCULOSIS IN RABBITS AFTER INTRAVENOUS INOCULATION WITH BOVINE TUBERCLE BACILLI. J Exp Med. 1932 Jul 31;56(2):185–202. doi: 10.1084/jem.56.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Wiseman B. K. THE INDUCTION OF LYMPHOCYTOSIS AND LYMPHATIC HYPERPLASIA BY MEANS OF PARENTERALLY ADMINISTERED PROTEIN. J Exp Med. 1931 Mar 31;53(4):499–510. doi: 10.1084/jem.53.4.499. [DOI] [PMC free article] [PubMed] [Google Scholar]

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