Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage

Abstract

The authors state that it came to their attention that the figure legends of two figures were not sufficiently detailed in the original version of the manuscript.

The figure legend of Fig 1E and F should read:

A single representative FACS plot was chosen to illustrate (E) the gating of LGR5^hi and LGR5^lo populations within the population of LGR5⁺ (GFP‐positive) intestinal cells and (F) the gating of LGR5^hi‐high, LGR5^hi‐low, LGR5^lo‐high, and LGR5^lo‐low populations. The same FACS plot is displayed in (E) and (F).

The figure legend of Fig 6C should read:

Representative Western blots of cell lysates for the expression of phospho‐p53 and cleaved caspase‐3 (each n = 3; see Source Data for this figure). Samples from a single experiment were divided into identical portions and probed for phospho‐p53 or cleaved casp3. The expression control of beta‐actin was conducted on the second aliquot of the samples and was run in parallel on a separate gel.

The corrections do not affect the original conclusions presented. We apologize for the lack of detail and any inconvenience it may have caused.

Editorial Note

These changes were based on the results of an investigation of the Leibniz Association. All authors agree with this correction.

Source data for Figure 6C.