Summary
Chick embryo tracheal organ cultures showed increased resistance to infection by a coronavirus after exposure to ascorbate, while chick respiratory epithelium and allantois-on-shell preparations showed no increase in resistance to infection by an influenza virus or a paramyxovirus.
Keywords: Infectious Disease, Influenza, Ascorbic Acid, Influenza Virus, Organ Culture
Footnotes
With 1 Figure
References
- 1.Anderson T. W., Beaton G. G., Corey P., Spero L. Winter illness and vitamin C: The effect of relatively low dose. Canad. Med. Assoc. J. 1975;112:823–826. [PMC free article] [PubMed] [Google Scholar]
- 2.Bolin D. W., Book L. Oxidation of ascorbic acid to dehydroascorbic acid. Science. 1947;106:451. doi: 10.1126/science.106.2758.451. [DOI] [PubMed] [Google Scholar]
- 3.Chalmers T. C. Effects of ascorbic acid on the common cold: An evaluation of the evidence. Amer. J. Med. 1975;58:532–536. doi: 10.1016/0002-9343(75)90127-8. [DOI] [PubMed] [Google Scholar]
- 4.Cherry J. D., Taylor-Robinson D. Large-quantity production of chicken embryo tracheal organ cultures and use in viral and mycoplasma studies. Appl. Microbiol. 1970;19:658–662. doi: 10.1128/am.19.4.658-662.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Dykes M. H., Meier P. Ascorbic acid and the common cold: Evaluation of its efficacy and toxicity. J. Amer. Med. Assoc. 1975;231:1073–1079. [PubMed] [Google Scholar]
- 6.de Fazekas St, Groth S., White D. O. An improved assay for the infectivity of influenza viruses. J. Hyg. 1958;56:151–163. doi: 10.1017/s0022172400037621. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Fenner F. Classification and nomenclature of viruses. Second Report of the International Committee on Taxonomy of Viruses. Intervirology. 1976;7:4–115. doi: 10.1159/000149938. [DOI] [PubMed] [Google Scholar]
- 8.Geber W. F., Lefkowitz S. S., Hung C. Y. Effect of ascorbic acid, sodium salicylate and caffeine on the serum interferon level in response to viral infection. Pharmacology. 1975;13:228–233. doi: 10.1159/000136908. [DOI] [PubMed] [Google Scholar]
- 9.Karlowski T. R., Chalmers T. C., Frenkel L. D., Kapikian A. Z., Lewis T. L., Lynch J. M. Ascorbic acid for the common cold: A prophylactic and therapeutic trial. J. Amer. Med. Assoc. 1975;231:1038–1042. [PubMed] [Google Scholar]
- 10.Moehring J. M., Stinebring W. R., Merchant D. J. Survey of interferon production and sensitivity in human cell lines. Appl. Microbiol. 1971;22:102–105. doi: 10.1128/am.22.1.102-105.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11.Murphy B. L., Krushak D. H., Maynard J. E., Bradley D. W. Ascorbic acid (vitamin C) and its effects on parainfluenza type 3 virus infection in cotton-topped marmosets. Lab. Anim. Sci. 1974;24:229–232. [PubMed] [Google Scholar]
- 12.Reed L. J., Muench H. A simple method of estimating fifty per cent end-points. Amer. J. Hygiene. 1938;27:493–497. [Google Scholar]
- 13.Schwartz A. R., Togo Y., Hornick R. B., Tominaga S., Gleckman R. A. Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man. J. inf. Dis. 1973;128:500–505. doi: 10.1093/infdis/128.4.500. [DOI] [PubMed] [Google Scholar]
- 14.Schwerdt P. R., Schwerdt C. E. Effect of ascorbic acid on rhinovirus replication in W 1–38 cells. Prof. Soc. exp. Biol. Med. 1975;148:1237–1243. doi: 10.3181/00379727-148-38724. [DOI] [PubMed] [Google Scholar]
- 15.Siegel B. V. Enhanced interferon response to murine leukemia virus by ascorbic acid. Infect. Immun. 1974;10:409–410. doi: 10.1128/iai.10.2.409-410.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Willis R. J., Kratzing C. C. Ascorbic acid in rat lung. Biochem. biophys. Res. Comm. 1974;59:1250–1253. doi: 10.1016/0006-291x(74)90448-3. [DOI] [PubMed] [Google Scholar]