Skip to main content
Springer Nature - PMC COVID-19 Collection logoLink to Springer Nature - PMC COVID-19 Collection
. 2006;581:531–534. doi: 10.1007/978-0-387-33012-9_96

HCoV-OC43–Induced Encephalitis is in Part Immune-Mediated

Noah Butler 3, Lecia Pewe 4, Kathryn Trandem 5, Stanley Perlman 6
Editors: Stanley Perlman1, Kathryn V Holmes2
PMCID: PMC7124118  PMID: 17037592

The content is available as a PDF (822.5 KB).

Contributor Information

Stanley Perlman, Email: Stanley-Perlman@uiowa.edu

Kathryn V. Holmes, Email: Kathryn.Holmes@ucHSC.edu

Stanley Perlman, Email: Stanley-Perlman@uiowa.edu

References

  • 1.McIntosh K, Becker WB, Chanock RM. Growth in suckling-mouse brain of "IBV-like" viruses from patients with upper respiratory tract disease. Proc. Natl. Acad. Sci. USA. 1967;58:2268–2273. doi: 10.1073/pnas.58.6.2268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Jacomy H, Talbot PJ. Vacuolating encephalitis in mice infected by human coronavirus OC43. Virology. 2003;315:20–33. doi: 10.1016/S0042-6822(03)00323-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Pewe L, Zhou H, Netland J, Tangadu C, Olivares H, Shi L, Look D, Gallagher TM, Perlman S. A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J. Virol. 2005;79:11335–11342. doi: 10.1128/JVI.79.17.11335-11342.2005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Krueger DK, Kelly SM, Lewicki DN, Ruffolo R, Gallagher TM. Variations in disparate regions of the murine coronavirus spike protein impact the initiation of membrane fusion. J. Virol. 2001;75:2792–2802. doi: 10.1128/JVI.75.6.2792-2802.2001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Joly E, Oldstone MB. Neuronal cells are deficient in loading peptides onto MHC class I molecules. Neuron. 1992;8:1185–1190. doi: 10.1016/0896-6273(92)90138-4. [DOI] [PubMed] [Google Scholar]
  • 6.Neumann H, Cavalie A, Jenne D, Wekerle H. Induction of MHC class I genes in neurons. Science. 1995;269:549–552. doi: 10.1126/science.7624779. [DOI] [PubMed] [Google Scholar]
  • 7.Neumann H, Schmidt H, Cavalie A, Jenne D, Wekerle H. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. J. Exp. Med. 1997;185:305–316. doi: 10.1084/jem.185.2.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Medana IM, Gallimore A, Oxenius A, Martinic MM, Wekerle H, Neumann H. MHC class I-restricted killing of neurons by virus-specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway. Eur. J. Immunol. 2000;30:3623–3633. doi: 10.1002/1521-4141(200012)30:12<3623::AID-IMMU3623>3.0.CO;2-F. [DOI] [PubMed] [Google Scholar]
  • 9.Gu J, Gong E, Zhang B, et al. Multiple organ infection and the pathogenesis of SARS. J. Exp. Med. 2005;202:415–424. doi: 10.1084/jem.20050828. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Nidoviruses are provided here courtesy of Nature Publishing Group

RESOURCES