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. 1977 Oct;36(5):413–419. doi: 10.1136/ard.36.5.413

Chronic synovitis with early cartilage destruction in sickle cell disease.

H R Schumacher, B B Dorwart, J Bond, A Alavi, W Miller
PMCID: PMC1000132  PMID: 921340

Abstract

Two patients with sickle cell disease presented with joint pain and early x-ray evidence of articular cartilage loss. Both later developed increasingly destructive arthritis with chronic synovitis identified in synovial biopsies. One patient developed demonstrable aseptic necrosis. Destructive arthropathy is much less common than the frequent transient effusions in sickle cell disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agudelo C. A., Schumacher H. R. The synovitis of acute gouty arthritis. A light and electron microscopic study. Hum Pathol. 1973 Jun;4(2):265–279. doi: 10.1016/s0046-8177(73)80013-9. [DOI] [PubMed] [Google Scholar]
  2. Dieppe P. A., Crocker P., Huskisson E. C., Willoughby D. A. Apatite deposition disease. A new arthropathy. Lancet. 1976 Feb 7;1(7954):266–269. doi: 10.1016/s0140-6736(76)91400-8. [DOI] [PubMed] [Google Scholar]
  3. Espinoza L. R., Spilberg I., Osterland C. K. Joint manifestations of sickle cell disease. Medicine (Baltimore) 1974 Jul;53(4):295–305. doi: 10.1097/00005792-197407000-00003. [DOI] [PubMed] [Google Scholar]
  4. Fink A. I. Vascular changes in the bulbar conjunctiva associated with sickle-cell disease: some observations on fine structure. Trans Am Ophthalmol Soc. 1968;66:788–826. [PMC free article] [PubMed] [Google Scholar]
  5. Goldberg M. A. Sickle cell arthropathy: analysis of synovial fluid in sickle cell anemia with joint effusion. South Med J. 1973 Aug;66(8):956–958. [PubMed] [Google Scholar]
  6. Hanissian A. S., Silverman A. Arthritis of sickle cell anemia. South Med J. 1974 Jan;67(1):28–32. doi: 10.1097/00007611-197401000-00009. [DOI] [PubMed] [Google Scholar]
  7. Johnston R. B., Jr, Newman S. L., Struth A. G. An abnormality of the alternate pathway of complement activation in sickle-cell disease. N Engl J Med. 1973 Apr 19;288(16):803–808. doi: 10.1056/NEJM197304192881601. [DOI] [PubMed] [Google Scholar]
  8. Orozco-Alcala J., Baum J. Arthritis during sickle-cell crisis. N Engl J Med. 1973 Feb 22;288(8):420–420. [PubMed] [Google Scholar]
  9. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  10. SHERMAN M. Pathogenesis of disintegration of the hip in sickle cell anemia. South Med J. 1959 Jun;52(6):632–637. doi: 10.1097/00007611-195906000-00002. [DOI] [PubMed] [Google Scholar]
  11. Schumacher H. R., Andrews R., McLaughlin G. Arthropathy in sickle-cell disease. Ann Intern Med. 1973 Feb;78(2):203–211. doi: 10.7326/0003-4819-78-2-203. [DOI] [PubMed] [Google Scholar]
  12. Strauss J., Koss M., Griswold W., Chernack W., Pardo V., McIntosh R. M. Letter: Cryoprecipitable immune complexes, nephropathy, and sickle-cell disease. Ann Intern Med. 1974 Jul;81(1):114–114. doi: 10.7326/0003-4819-81-1-114. [DOI] [PubMed] [Google Scholar]
  13. Walker B. R., Alexander F., Birdsall T. R., Warren R. L. Glomerular lesions in sickle cell nephropathy. JAMA. 1971 Jan 18;215(3):437–440. [PubMed] [Google Scholar]

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