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. 1978 Feb;37(1):12–17. doi: 10.1136/ard.37.1.12

Antigammaglobulin (rheumatoid factor) activity of human IgG subclasses.

F Shakib, D R Stanworth
PMCID: PMC1000181  PMID: 629598

Abstract

A sensitive radioimmunoassay has been applied to the study of rheumatoid factor activity of IgM and IgG subclasses in serum and synovial fluid of patients with rheumatoid arthritis. Although rheumatoid factor activity was found in all four subclasses, its distribution was not the same as that of the total subclasses in normal sera. Results are discussed in relation to the possible clinical value of measuring IgG rheumatoid factor in sera and synovial fluids of patients with rheumatoid arthritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abruzzo J. L., Heimer R. IgG anti-IgG antibodies in rheumatoid arthritis and certain other conditions. Ann Rheum Dis. 1974 May;33(3):258–261. doi: 10.1136/ard.33.3.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Abruzzo J. L., Heimer R. The measurement of IgG anti-IgG antibody in rheumatoid arthritis. J Immunol Methods. 1974 Mar;4(2):149–160. doi: 10.1016/0022-1759(74)90057-x. [DOI] [PubMed] [Google Scholar]
  3. Augener W., Grey H. M., Cooper N. R., Müller-Eberhard H. J. The reaction of monomeric and aggregated immunoglobulins with C1. Immunochemistry. 1971 Nov;8(11):1011–1020. doi: 10.1016/0019-2791(71)90489-7. [DOI] [PubMed] [Google Scholar]
  4. Hawker R. J., Hawker L. M. A rapidly produced 125I labelled autologous fibrinogen: in vitro properties and preliminary metabolic studies in man. J Clin Pathol. 1976 Jun;29(6):495–501. doi: 10.1136/jcp.29.6.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hay F. C., Nineham L. J., Roitt I. M. Routine assay for detection of IgG and IgM antiglobulins in seronegative and seropositive rheumatoid arthritis. Br Med J. 1975 Jul 26;3(5977):203–204. doi: 10.1136/bmj.3.5977.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hay F. C., Torrigiani G. The distribution of anti-thyroglobulin antibodies in the immunoglobulin G subclasses. Clin Exp Immunol. 1973 Dec;15(4):517–521. [PMC free article] [PubMed] [Google Scholar]
  7. Ilter O. D., Turner M. W. Determination of IgG antiglobulins in rheumatoid disease using insolubilized human IgG. Clin Exp Immunol. 1973 Sep;15(1):93–101. [PMC free article] [PubMed] [Google Scholar]
  8. Lewis E. J., Busch G. J., Schur P. H. Gamma G globulin subgroup composition of the glomerular deposits in human renal diseases. J Clin Invest. 1970 Jun;49(6):1103–1113. doi: 10.1172/JCI106326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McPhaul J. J., Jr, Dixon F. J. Characterization of immunoglobulin G anti-glomerular basement membrane antibodies eluted from kidneys of patients with glomerulonephritis. II. IgG subtypes and in vitro complement fixation. J Immunol. 1971 Sep;107(3):678–684. [PubMed] [Google Scholar]
  10. Okafor G. O., Turner M. W., Greenwood B. M. Antiglobulins in Nigerians with rheumatoid disease. Ann Rheum Dis. 1975 Apr;34(2):142–145. doi: 10.1136/ard.34.2.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shakib F., Stanworth D. R., Drew R., Catty D. A quantitative study of the distribution of IgG sub-classes in a group of normal human sera. J Immunol Methods. 1975;8(1-2):17–28. doi: 10.1016/0022-1759(75)90077-0. [DOI] [PubMed] [Google Scholar]
  12. Shakib F., Stanworth D. R. IgG subclass composition of rheumatoid arthritic sera and joint fluids. Ann Rheum Dis. 1976 Jun;35(3):263–266. doi: 10.1136/ard.35.3.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tojo T., Friou G. J., Spiegelberg H. L. Immunoglobulin G subclass of human antinuclear antibodies. Clin Exp Immunol. 1970 Jan;6(1):145–151. [PMC free article] [PubMed] [Google Scholar]
  14. Torrigiani G., Roitt I. M. Antiglobulin factors in sera from patients with rheumatoid arthritis and normal subjects. Quantitative estimation in different immunoglobulin classes. Ann Rheum Dis. 1967 Jul;26(4):334–340. doi: 10.1136/ard.26.4.334. [DOI] [PMC free article] [PubMed] [Google Scholar]

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