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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1978 Feb;37(1):67–70. doi: 10.1136/ard.37.1.67

Serum copper and related variables in rheumatoid arthritis.

P R Scudder, D Al-Timimi, W McMurray, A G White, B C Zoob, T L Dormandy
PMCID: PMC1000192  PMID: 629607

Abstract

Serum copper, caeruloplasmin, iron, iron-binding capacity, and antioxidant activity were measured in 120 normal subjects and in 189 patients with rheumatoid arthritis. Both serum copper and serum caeruloplasmin were significantly raised in rheumatoid disease in both sexes. A significant inverse relation was found between serum iron and serum copper, and a strong direct correlation between serum antioxidant activity and caeruloplasmin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Al-Timimi D. J., Dormandy T. L. The inhibition of lipid autoxidation by human caeruloplasmin. Biochem J. 1977 Nov 15;168(2):283–288. doi: 10.1042/bj1680283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bajpayee D. P. Significance of plasma copper and caeruloplasmin concentrations in rheumatoid arthritis. Ann Rheum Dis. 1975 Apr;34(2):162–165. doi: 10.1136/ard.34.2.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Balázs N. D., Pole D. J., Masarei J. R. Determination of gold in body fluids by atomic absorption spectrophotometry. Clin Chim Acta. 1972 Aug;40(1):213–218. doi: 10.1016/0009-8981(72)90273-2. [DOI] [PubMed] [Google Scholar]
  4. Bidlack W. R., Tappel A. L. Damage to microsomal membrane by lipid peroxidation. Lipids. 1973 Apr;8(4):177–182. doi: 10.1007/BF02544631. [DOI] [PubMed] [Google Scholar]
  5. Jayson M. I., Davis P., Whicher J. T., Walters G. Serum copper and caeruloplasmin in ankylosing spondylitis, systemic sclerosis, and morphea. Ann Rheum Dis. 1975 Oct;35(5):443–445. doi: 10.1136/ard.35.5.443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Koskelo P., Kekki M., Virkkunen M., Lassus A., Somer T. Serum ceruloplasmin concentration in rheumatoid arthritis, ankylosing spondylitis, psoriasis and sarcoidosis. Acta Rheumatol Scand. 1966;12(4):261–266. doi: 10.3109/rhe1.1966.12.issue-1-4.31. [DOI] [PubMed] [Google Scholar]
  7. Lorber A., Cutler L. S., Chang C. C. Serum copper levels in rheumatoid arthritis: relationship of elevated copper to protein alterations. Arthritis Rheum. 1968 Feb;11(1):65–71. doi: 10.1002/art.1780110109. [DOI] [PubMed] [Google Scholar]
  8. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  9. McMurray W., Martin V. M., Scudder P., Stocks J., White A. G., Dormandy T. L. Urinary copper excretion in rheumatoid arthritis. Ann Rheum Dis. 1975 Aug;34(4):340–345. doi: 10.1136/ard.34.4.340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sternlieb I., Sandson J. I., Morell A. G., Korotkin E., Scheinberg I. H. Nonceruloplasmin copper in rheumatoid arthritis. Arthritis Rheum. 1969 Aug;12(4):458–460. doi: 10.1002/art.1780120414. [DOI] [PubMed] [Google Scholar]
  11. Stocks J., Gutteridge J. M., Sharp R. J., Dormandy T. L. Assay using brain homogenate for measuring the antioxidant activity of biological fluids. Clin Sci Mol Med. 1974 Sep;47(3):215–222. doi: 10.1042/cs0470215. [DOI] [PubMed] [Google Scholar]
  12. Stocks J., Gutteridge J. M., Sharp R. J., Dormandy T. L. The inhibition of lipid autoxidation by human serum and its relation to serum proteins and alpha-tocopherol. Clin Sci Mol Med. 1974 Sep;47(3):223–233. doi: 10.1042/cs0470223. [DOI] [PubMed] [Google Scholar]
  13. YOUNG D. S., HICKS J. M. METHOD FOR THE AUTOMATIC DETERMINATION OF SERUM IRON. J Clin Pathol. 1965 Jan;18:98–102. doi: 10.1136/jcp.18.1.98. [DOI] [PMC free article] [PubMed] [Google Scholar]

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