Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1978 Aug;37(4):333–338. doi: 10.1136/ard.37.4.333

The relationship between uric acid and potassium in normal subjects.

A C Kennedy, K Boddy, P C King, J Brennan, J A Anderson, W W Buchanan
PMCID: PMC1000239  PMID: 686865

Abstract

The serum uric acid concentration in normal healthy subjects has been studied in relation to sex, height, weight, lean body mass measured from total body potassium and predicted from the Hume-Weyers formula (1971), total body potassium, plasma potassium and urea, and packed cell volume. The strongest correlation was found with sex, but height, weight, total body potassium, lean body mass (measured and predicted) also correlated significantly with serum uric acid concentration. However, when the sex variable was removed, the other factors lost their significant correlation. Finally, total red blood cell and plasma volumes were predicted (Hume and Goldberg, 1964) and from these an estimate of total plasma uric acid, total plasma potassium, and total red blood cell potassium obtained. Measured total body potassium was found to correlate well with total plasma potassium and total red blood cell potassium independent of sex. Total plasma uric acid correlated well with measured total body potassium when both sexes were considered and when separated into male and female groups the males retained a significant correlation as did the female group.

Full text

PDF
333

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acheson R. M., Florey C. du V. Body-weight, ABO blood-groups, and altitude of domicile as determinants of serum-uric-acid in military recruits in four countries. Lancet. 1969 Aug 23;2(7617):391–394. doi: 10.1016/s0140-6736(69)90107-x. [DOI] [PubMed] [Google Scholar]
  2. Acheson R. M., O'Brien W. M. Dependence of serum-uric-acid on haemoglobin and other factors in the general population. Lancet. 1966 Oct 8;2(7467):777–778. doi: 10.1016/s0140-6736(66)90368-0. [DOI] [PubMed] [Google Scholar]
  3. Boddy K. A high sensitivity shadow-shield whole body monitor with scanning-bed and tilting chair geometries, incorporated in a mobile laboratory. Br J Radiol. 1967 Aug;40(476):631–637. doi: 10.1259/0007-1285-40-476-631. [DOI] [PubMed] [Google Scholar]
  4. Boddy K., Hume R., White C., Pack A., King P. C., Weyers E., Rowan T., Mills E. The relation between potassium in body fluids and total body potassium in healthy and diabetic subjects. Clin Sci Mol Med. 1976 Jun;50(6):455–461. doi: 10.1042/cs0500455. [DOI] [PubMed] [Google Scholar]
  5. Boddy K., King P. C., Hume R., Weyers E. The relation of total body potassium to height, weight, and age in normal adults. J Clin Pathol. 1972 Jun;25(6):512–517. doi: 10.1136/jcp.25.6.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Boddy K., King P. C., Tothill P., Strong J. A. Measurement of total body potassium with a shadow shield whole-body counter: calibration and errors. Phys Med Biol. 1971 Apr;16(2):275–282. doi: 10.1088/0031-9155/16/2/310. [DOI] [PubMed] [Google Scholar]
  7. Boyd D. W. Red-blood-cell potassium and aldosteronism. Lancet. 1970 Mar 21;1(7647):594–595. doi: 10.1016/s0140-6736(70)91630-2. [DOI] [PubMed] [Google Scholar]
  8. Boyle J. A., Greig W. R., Jasani M. K., Duncan A., Diver M., Buchanan W. W. Relative roles of genetic and environmental factors in the control of serum uric acid levels in normouricaemic subjects. Ann Rheum Dis. 1967 May;26(3):234–238. doi: 10.1136/ard.26.3.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Brooks G. W., Mueller E. Serum urate concentrations among university professors; relation to drive, achievement, and leadership. JAMA. 1966 Feb 7;195(6):415–418. [PubMed] [Google Scholar]
  10. Burch T. A., O'Brien W. M., Need R., Kurland L. T. Hyperuricaemia and gout in the Mariana Islands. Ann Rheum Dis. 1966 Mar;25(2):114–116. doi: 10.1136/ard.25.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Emmerson B. T., Douglas W., Doherty R. L., Feigl P. Serum urate concentrations in the Australian aboriginal. Ann Rheum Dis. 1969 Mar;28(2):150–156. doi: 10.1136/ard.28.2.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Evans J. G., Prior I. A., Harvey H. P. Relation of serum uric acid to body bulk, haemoglobin, and alcohol intake in two South Pacific Polynesian populations. Ann Rheum Dis. 1968 Jul;27(4):319–325. doi: 10.1136/ard.27.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HUME R., GOLDBERG A. ACTUAL AND PREDICTED-NORMAL RED-CELL AND PLASMA VOLUMES IN PRIMARY AND SECONDARY POLYCYTHAEMIA. Clin Sci. 1964 Jun;26:499–508. [PubMed] [Google Scholar]
  14. Healey L. A., Jones K. W. Hyperuricemia in American Samoans. Arthritis Rheum. 1971 Mar-Apr;14(2):283–285. doi: 10.1002/art.1780140215. [DOI] [PubMed] [Google Scholar]
  15. Hume R., Weyers E. Relationship between total body water and surface area in normal and obese subjects. J Clin Pathol. 1971 Apr;24(3):234–238. doi: 10.1136/jcp.24.3.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kasl S. V., Brooks G. W., Cobb S. Serum urate concentrations in male high-school students. JAMA. 1966 Nov 14;198(7):713–716. [PubMed] [Google Scholar]
  17. Kasl S. V., Brooks G. W., Rodgers W. L. Serum uric acid and cholesterol in achievement behavior and motivation. I. The relationship to ability, grades, test performance, and motivation. JAMA. 1970 Aug 17;213(7):1158–1164. [PubMed] [Google Scholar]
  18. Krízek V. Serum uric acid in relation to body weight. Ann Rheum Dis. 1966 Sep;25(5):456–458. [PMC free article] [PubMed] [Google Scholar]
  19. Laing J. K., Murray J. T. Serum uric acid levels in New Zealanders. N Z Med J. 1973 Jul 25;78(495):65–67. [PubMed] [Google Scholar]
  20. MIKKELSEN W. M., DODGE H. J., VALKENBURG H. THE DISTRIBUTION OF SERUM URIC ACID VALUES IN A POPULATION UNSELECTED AS TO GOUT OR HYPERURICEMIA: TECUMSEH, MICHIGAN 1959-1960. Am J Med. 1965 Aug;39:242–251. doi: 10.1016/0002-9343(65)90048-3. [DOI] [PubMed] [Google Scholar]
  21. Mikkelsen W. M. The possible association of hyperuricemia and/or gout with diabetes mellitus. Arthritis Rheum. 1965 Oct;8(5):853–864. doi: 10.1002/art.1780080450. [DOI] [PubMed] [Google Scholar]
  22. Nicholls A., Scott J. T. Effect of weight-loss on plasma and urinary levels of uric acid. Lancet. 1972 Dec 9;2(7789):1223–1224. doi: 10.1016/s0140-6736(72)92271-4. [DOI] [PubMed] [Google Scholar]
  23. Nicholls A., Snaith M. L., Scott J. T. Effect of oestrogen therapy on plasma and urinary levels of uric acid. Br Med J. 1973 Feb 24;1(5851):449–451. doi: 10.1136/bmj.1.5851.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Nuki G., Boddy K., Kennedy A. C., King P., Duncan A. M., Buchanan W. W. Potassium metabolism in patients with rheumatoid arthritis. Effects of treatment with depot tetracosactrin, spironolactone, and oral supplements of potassium chloride. Ann Rheum Dis. 1975 Dec;34(6):506–514. doi: 10.1136/ard.34.6.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. O'Brien W. M., Burch T. A., Bunim J. J. Genetics of hyperuricaemia in Blackfeet and Pima Indians. Ann Rheum Dis. 1966 Mar;25(2):117–119. doi: 10.1136/ard.25.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. PRIOR I. A., ROSE B. S., DAVIDSON F. METABOLIC MALADIES IN NEW ZEALAND MAORIS. Br Med J. 1964 Apr 25;1(5390):1065–1069. doi: 10.1136/bmj.1.5390.1065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Prior I. A., Rose B. S. Uric acid, gout and public health in the South Pacific. N Z Med J. 1966 May;65(405):295–300. [PubMed] [Google Scholar]
  28. Reed D., Labarthe D., Stallones R. Epidemiologic studies of serum uric acid levels among Micronesians. Arthritis Rheum. 1972 Jul-Aug;15(4):381–390. doi: 10.1002/art.1780150409. [DOI] [PubMed] [Google Scholar]
  29. Zalokar J., Lellouch J., Claude J. R., Kuntz D. Serum uric acid in 23,923 men and gout in a subsample of 4257 men in France. J Chronic Dis. 1972 May;25(5):305–312. doi: 10.1016/0021-9681(72)90166-x. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES