Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1978 Aug;37(4):351–356. doi: 10.1136/ard.37.4.351

Intra-articular methotrexate. Clinical and laboratory study in rheumatoid and psoriatic arthritis.

G H Hall, B J Jones, A C Head, V E Jones
PMCID: PMC1000243  PMID: 356763

Abstract

The effects of intra-articular methotrexate (MTX) were compared with saline in 20 patients with persistent knee effusions due to rheumatoid arthritis (15) and psoriasis (5) in a double-blind pilot study. Clinical improvement was seen in most patients given either MTX or saline and was attributed to joint irrigation during arthroscopy and the placebo effects. MTX had a local anti-inflammatory effect in the psoriatic arthropathies; the percentages of polymorphonuclear cells and pyroninophilic mononuclear cells in synovial fluids fell sharply. Intraarticular hydrocortisone acetate was not anti-inflammatory in 2 psoriatic patients treated subsequently. The anti-inflammatory action of MTX in joints may resemble its effectiveness in controlling the rash of psoriasis.

Full text

PDF
351

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLACK R. L., O'BRIEN W. M., VANSCOTT E. J., AUERBACH R., EISEN A. Z., BUNIM J. J. METHOTREXATE THERAPY IN PSORIATIC ARTHRITIS; DOUBLE-BLIND STUDY ON 21 PATIENTS. JAMA. 1964 Sep 7;189:743–747. [PubMed] [Google Scholar]
  2. Bertino J. R. Chemical action and pharmacology of methotrexate, azathioprine and cyclophosphamide in man. Arthritis Rheum. 1973 Jan-Feb;16(1):79–83. doi: 10.1002/art.1780160113. [DOI] [PubMed] [Google Scholar]
  3. Chabner B. A., Myers C. E., Coleman C. N., Johns D. G. The clinical pharmacology of antineoplastic agents (first of two parts). N Engl J Med. 1975 May 22;292(21):1107–1113. doi: 10.1056/NEJM197505222922107. [DOI] [PubMed] [Google Scholar]
  4. Goetzl E. J., Bianco N. E., Alpert J. S., Sledge C. B., Schur P. H. Effects of intra-articular corticosteroids in vivo on synovial fluid variables in rheumatoid synovitis. Ann Rheum Dis. 1974 Jan;33(1):62–66. doi: 10.1136/ard.33.1.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hall G. H., Head A. C. Letter: Intra-articular methotrexate. Lancet. 1975 Aug 30;2(7931):409–409. doi: 10.1016/s0140-6736(75)92925-6. [DOI] [PubMed] [Google Scholar]
  6. Hay F. C., Nineham L. J., Roitt I. M. Routine assay for detection of IgG and IgM antiglobulins in seronegative and seropositive rheumatoid arthritis. Br Med J. 1975 Jul 26;3(5977):203–204. doi: 10.1136/bmj.3.5977.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. JOHANSEN P. E. SYNOVIAL LINING CELLS AND PLASMA CELLS IN THE SYNOVIAL MEMBRANE IN CASES OF CLASSIC RHEUMATOID ARTHRITIS. A STUDY BASED PARTLY ON HISTOLOGICAL SECTIONS STAINED BY THE METHYL GREEN-PYRONINE METHOD. Acta Rheumatol Scand. 1965;11:4–14. doi: 10.3109/rhe1.1965.11.issue-1-4.01. [DOI] [PubMed] [Google Scholar]
  8. Marks J. S., Stewart I. M., Hunter J. A. Intra-articular methotrexate in rheumatoid arthritis. Lancet. 1976 Oct 16;2(7990):857–858. doi: 10.1016/s0140-6736(76)91250-2. [DOI] [PubMed] [Google Scholar]
  9. Weinstein G. D. Methotrexate. Ann Intern Med. 1977 Feb;86(2):199–204. doi: 10.7326/0003-4819-86-2-199. [DOI] [PubMed] [Google Scholar]
  10. White J. C., Loftfield S., Goldman I. D. The mechanism of action of methotrexate. III. Requirement of free intracellular methotrexate for maximal suppression of (14C)formate incorporation into nucleic acids and protein. Mol Pharmacol. 1975 May;11(3):287–297. [PubMed] [Google Scholar]
  11. Williamson N., James K., Ling N. R., Holt L. P. Synovial cells. A study of the morphology and an examination of protein synthesis of synovial cells. Ann Rheum Dis. 1966 Nov;25(6):534–546. doi: 10.1136/ard.25.6.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ziff M. Relation of cellular infiltration of rheumatoid synovial membrane to its immune response. Arthritis Rheum. 1974 May-Jun;17(3):313–319. doi: 10.1002/art.1780170317. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES